The association between prostate cancer and baseline vitamin E and selenium was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 29,133). During up to 9 years of follow-up, 317 men developed incident prostate cancer. Multivariate Cox proportional hazards models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking...

BACKGROUND The immune system provides protection against infectious diseases or other insults. Psychological stress may alter antibody production through neurobiological pathways. Antioxidant supplementation is thought to improve immune status and thereby reduce infectious morbidity. The aim of this study was to determine the preventive effect of ascorbic acid and alpha tocopherol on immune sta...

In this study, the oil contents, fatty acid composition and tocopherol contents of sesame seed and oils belong to different countries were determined. The oil contents of materials changed between 49.22% (India) and 56.16% (Nigeria-Kanu). The major saturated fatty acids in sesame seed oils were palmitic (6.06-9.03%), stearic (5.29-6.42%) acids with small 20:0 (0.19-0.71%) acids. The main un...

This study was performed to investigate the effect of Ag+ as an elicitor on the activity of antioxidant enzymes, content of H2O2, accumulation of total tocopherol and antioxidant activity in hairy root cultures of Silybum marianum (L.) Gaertn. The hairy roots were treated with 2 mM Ag+. The treated and non-treated hairy roots were harvested in the same time and data on H2O2 content, DPPH, tocop...

Deltamethrin is a broad-spectrum insecticide mainly used to protect crops, fruit and vegetables from mites, ants, weevils, beetle etc. Thus deltamethrin contaminated food of commercial poultry diet may cause toxic effects in broilers and indirect adverse effects on human through food chain. Therefore, hematological and biochemical alterations in White Leghorn birds due to deltamethrin induced t...

We previously found that 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (γCEHC), a metabolite of the vitamin E isoforms γ-tocopherol or γ-tocotrienol, accumulated in the rat small intestine. The aim of this study was to evaluate tissue distribution of vitamin E metabolites. A single dose of α-tocopherol, γ-tocopherol or a tocotrienol mixture containing α- and γ-tocotrienol was orally admin...

BACKGROUND Oxidative stress during HIV infection may impair immune function, cause more rapid disease progression, and increase requirements for dietary antioxidants such as vitamins C and E. OBJECTIVES The study had 2 principal objectives. The first was to ascertain whether HIV infection and immune activation were associated with lower plasma concentrations of ascorbate, urate, and alpha- an...

The aim of this work was to compare protective and anti-apoptotic effects of α-tocopherol at nanomolar and micromolar concentrations against 0.2 mM H(2)O(2)-induced toxicity in the PC12 neuronal cell line and to reveal protein kinases that contribute to α-tocopherol protective action. The protection by 100 nM α-tocopherol against H(2)O(2)-induced PC12 cell death was pronounced if the time of pr...

The relative bioavailability of polysaccharide--racemic vitamin E preparation in comparison with a commercial product was assessed in a kinetic study of plasma alpha-tocopherol in rabbits. Six male rabbits were used in a cross-over design. Alpha-Tocopherol levels were determined by the fluorometric method. A secondary peak in alpha-Tocopherol plasma concentration--time profiles was observed in ...

This study analyzed the chemical composition and β-carotene, tocopherol retinol content of meat (musculus longissimus lumborum, musculus gluteus maximus) from young rams fed different silage-based diets. The animals were divided into four groups depending on type silage in feed ration (hybrid ryegrass, Festulolium cv. Becva, Felopa, Paulita). concentrations examined lipophilic compounds measure...