Pachystigma pygmaeum is one of several species of rubiaceous plants which cause delayed heart failure among ruminants after their ingestion at relatively high doses. Using guinea-pigs for toxicity determinations, we were able to separate and enrich a toxic fraction from a fermentation extract of the plant material by countercurrent distribution. It contained virtually no potassium salts, passed...

The toxic cellular component of Group A streptococci, which produces a chronic multinodular lesion of the dermal connective tissue of rabbits, has been isolated by means of differential centrifugation and electrophoresis. The substance appeared to be a macromolecular complex of polysaccharide and protein, the polysaccharide having the serological and chemical characteristics of the group-specif...

Abstract Hydroxyapatite has been synthesized as a bone graft material by analyzing the membrane made according to cytotoxicity test and bending test. The method used is dry ball milling. Cytotoxicity testing was carried out making isolated osteoblast cells cultured in 75 cm 2 cell flask containing minimum of essential media. Based on test, it found that hydroxyapatite not toxic with viability a...

Paralysis in man and the domestic fowl caused by "ToCP" (tri-cresyl phosphate, tri-tolyl phosphate or TTP) is reviewed, and the search for a non-toxic plasticizer derived either from TTP or tri-xylenyl phosphate (tri-dimethylphenyl phosphate or TXP) is described. It had been previously shown that the ortho-tolyl esters are toxic but we found that their removal does not make the mixture non-toxi...

diabetes mellitus (dm) is a metabolic disorder resulting from a defect in insulin secretion, insulin action or both. despite the fact that it has a worldwide high prevalence, morbidity and mortality, it is regarded as a non–curable but controllable disease. in addition to different synthetic drugs, plant remedies and dietary traditions play an effective role in treatment. teucrium polium l. is ...

"Toxic" neutrophils from humans with severe bacterial infections, identified by the presence of Döhle bodies, "toxic" granules, and vacuoles were shown to differ from normal neutrophils both in ultrastructure and in lysosome activity. Döhle bodies were identified as lamellar aggregates of rough endoplasmic reticulum. Toxic granules corresponded to the azurophilic granules usually identified by ...

A 43 year old woman in remission from acute myeloid leukaemia developed abdominal pain, severe melaena, diarrhoea and gram-negative septicaemia whilst severely pancytopenic following consolidation chemotherapy. Subsequently, serial abdominal X-rays showed a progressive toxic megacolon. Conservative management was attempted but, because of radiological evidence of increasing colonic dilatation a...

Toxic megacolon complicating inflammatory or infective colitis carries a high morbidity and mortality and surgical intervention is necessary in up to 80% of cases. Perforation complicates toxic megacolon in about 35% of cases. After perforation, the death rate nears 50%. Gaseous distension of the bowel causes considerable discomfort to the patient and increases transmural pressure. The latter i...

The gross and microscopic pathomorphological changes in internal organs were investigated for evaluation of the toxic effect of the triazole fungicide triticonazole. One control and three experimental groups of pigs, treated orally via a gastic tube at doses of 0.2 g/kg (group I), 1 g/kg (group II) and 2 g/kg (group III) (0.1LD50, 0.5LD50 and LD50 respectively) were used. The pigs were euthaniz...

The results which follow the injection of toxic proteoses in normal and immune dogs have been reported in a previous communication. 1 The proteose material was obtained from intestinal obstruction or from closed loops of the intestine. The present paper deals with the reaction which develops in the dog following intestinal obstruction of a certain type or the isolation of closed intestinal loop...