BACKGROUND Adenocarcinoma of unknown primary comprises up to 10% of metastatic malignant disease. With few exceptions this diagnosis carries a very poor prognosis of a few months with minimal survival advantage to chemotherapy. However there is the possibility that chemotherapy can improve symptom control and quality of life. PATIENTS AND METHODS Forty-four patients with adenocarcinoma of unk...

Exposure monitoring by personal diffusive samplers, biological monitoring of toluene exposure by urinary hippuric acid determination, haematology, serum biochemistry for liver function, and a subjective symptom survey by questionnaire were conducted on 303 male solvent workers. They were exposed to a mixture of solvents including toluene (geometric mean 18 ppm), methyl ethyl ketone (MEK; 16 ppm...

Palliative chemotherapy is defined as treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor-related symptoms, and where the palliation/toxicity trade-off from treatment clearly favors symptom relief. The role of chemotherapy in circumstances where little or no survival benefit is anticipat...

The CyberKnife is a robotic stereotactic body radiotherapy (SBRT) system which has shown promising results for many malignances with good efficacy and low toxicity. This study aims to evaluate the response and local control (LC) obtained with CyberKnife in the management of iliac lymph node metastases (ILNM). Twenty-two patients with 27 ILNM were treated by CyberKnife from May 2010 to May 2016....

Use of oral chemotherapy or targeted agents is shifting how cancer treatment is administered, moving it from supervised office visits to self-administration at home. This study examines issues related to overadherence to oral agents that were noted during a trial conducted by the authors comparing an automated voice system to strategies to reduce symptom severity and improve adherence. Overadhe...

PURPOSE Accurate assessment of toxicity allows for timely delivery of supportive measures during radiation therapy for head and neck cancer. The current paradigm requires weekly evaluation of patients by a provider. The purpose of this study is to evaluate the feasibility of monitoring patient reported symptoms via mobile devices. METHODS AND MATERIALS We developed a mobile application for pa...

conclusions relaxation with guided imagery had a positive effect on mediating anxiety and depression in breast cancer patients. results the experimental group showed significant decreases in insomnia (-0.34 ± 0.83, p < 0.05), pain (-0.28 ± 0.58, p < 0.05), anxiety (-3.56 ± 2.94, p < 0.00), and depression (-2.38 ± 2.70, p < 0.00) between the pretest and the posttest. comparing the two groups, st...

normal 0 false false false en-us x-none ar-sa background: the relation between vitamin d deficiency with depressive and fatigue symptoms in both multiple sclerosis (ms) patients and healthy population have been reported. to represent our regional achievement in this field we investigated the relation between vitamin d status with fatigue and depressive symptoms in ms patients. materials and met...

purpose: to determine the distribution of oculomotor, abducens, and trochlear nerve palsies in diabetic patients with ocular nerve palsy. methods: this study was performed on all diabetic patients who referred to ophthalmology and neurology clinics at yazd medical science university because of ocular palsy from march 2004 to october 2005. signs and symptoms of the disorder were evaluated. resul...

objectives: nowadays, spinal cord lesions, specially its injury, is one of the diseases/injuries that human-being is been affected by. it not only causes irreversible economical/social/cultural problems & uncompensated costs to the patient’s family & society but also, makes active peoples to inactive & needy ones. till now, there is no successful treatment for these patients so this ailment, it...