BACKGROUND We evaluated the clinical significance and prognostic value of histopathological features of bladder cancer, such as subepithelial growth patterns and tumor growth pattern at the invasion front. METHODS In total, 130 patients newly diagnosed with non-muscle invasive bladder cancer and underwent transurethral resection between 1998 and 2009 were enrolled. Subepithelial growth patter...

Introduction: Predictors of fracture risk differ between cervical and trochanteric hip fractures. The aim of this experimental study was therefore to investigate whether two-dimensional (2D) finite element (FE) models, generated from standard radiographs, are able to predict and discriminate fracture types, originating from a simulated fall on the greater trochanter. Methods: A semi-automatic c...

Parathyroid adenomas are benign encapsulated neoplasms that are typically comprised of chief cells and feature a rim of normal parathyroid tissue at their periphery. A small subset can be classified as atypical based on the presence of some histologic features of malignancy, such as a trabecular growth pattern, increased mitotic activity, capsular invasion, and fibrous bands, without definitive...

PURPOSE The present study hypothesized that different bone healing patterns through initial stages of osseointegration would be observed when three distinct commercially available implant systems (Nobel Groovy, Implacil, and Zimmer TSV) were used, leading to significant variations in histometric levels of total bone and new bone formation during the osseointegration process. MATERIALS AND MET...

The angiographic and haemodynamic findings in 2 cases of Pompe's disease (glycogenosis type II) indicated an abnormal trabecular pattern, not previously reported, on the left ventricular angiogram of both patients. This feature may be helpful in distinguishing Pompe's disease from other forms of myocardial abnormality.

Primary Ewing's sarcoma (ES) of the spine is uncommon, exhibiting a variety of appearances on plain-film radiographs and cross-sectional images. We report the unusual CT imaging manifestations of a primary ES with a coarse trabecular pattern that mimicked an aggressive hemangioma of the cervical spine.

background: the trabecular bone changes in the tibia of c3h/hen mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 gy) or 137cs-generated gamma-rays (0-6 gy). materials and methods: serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. tibiae were analyzed using microcomputed tomography. biomechanical...

Our purpose in this study was (i) to measure trabecular bone structure using fractal analysis of distal radius radiographs in subjects with and without osteoporotic hip fractures, and (ii) to compare these measures with bone mineral density (BMD) as well as with measures of trabecular bone structure derived from high resolution magnetic resonance (MR) images. Distal radius radiographs were obta...

Wang, Liming, Shiguang Liu, L. Darryl Quarles, and Robert F. Spurney. Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. Am J Physiol Endocrinol Metab 288: E826–E834, 2005. First published December 7, 2004; doi:10.1152/ajpendo.00422.2004.—To investigate the role of G protein-coupled receptor kinases (GRKs) in regulating bone formation in vivo, we o...

To investigate the role of G protein-coupled receptor kinases (GRKs) in regulating bone formation in vivo, we overexpressed the potent G protein-coupled receptor (GPCR) regulator GRK2 in osteoblasts, using the osteocalcin gene-2 promoter to target expression to osteoblastic cells. Using the parathyroid hormone (PTH) receptor as a model system, we found that overexpression of GRK2 in osteoblasts...