نتایج جستجو برای: transaminitis
تعداد نتایج: 252 فیلتر نتایج به سال:
This phase I trial examined the safety, pharmacokinetics, and pharmacodynamics of MLN8054, an oral, selective, small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received increasing doses of MLN8054 in 28-day cycles until dose-limiting toxicity (DLT) was seen in ≥2 of 3-6 patients in a cohort. For the 10-mg and 20-mg cohorts, treatment was administered once daily o...
Purpose: Urelumab is an agonist antibody to CD137 with potential application as an immuno-oncology therapeutic. Data were analyzed to assess safety, tolerability, and pharmacodynamic activity of urelumab, including the dose selected for ongoing development in patients with advanced solid tumors and lymphoma.Experimental Design: A total of 346 patients with advanced cancers who had progressed af...
nloaded phase I trial examined the safety, pharmacokinetics, and pharmacodynamics of MLN8054, an oral, ve, small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received increasses of MLN8054 in 28-day cycles until dose-limiting toxicity (DLT) was seen in ≥2 of 3-6 patients in a . For the 10-mg and 20-mg cohorts, treatment was administered once daily on days 1 to 5 an...
This case report describes an unusual presentation of an emergency department (ED) patient with nausea, vomiting, and epigastric pain, who was initially suspected of having viral hepatitis. The patient returned to the ED seven days later with persistent tachycardia and was diagnosed with new onset thyrotoxicosis.
Abstract Background NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window reperfusion therapy. Studies have proven its efficacy in ischemic stroke; however, data drug safety and combination with other medications especially anticoagulants are heterogenous. We report possible case hepatotoxicity induced by anticoagulants. Case presentation an e...
As many prior case reports have shown, unregulated supplements and alcohol are both known to cause varying degrees of hepatotoxicity. We present a 47-year-old male who presented the hospital with headache abdominal pain after consuming Reishi Mushroom (Ganoderma lingzhi) powder alcohol. The patient was found acute hepatitis significant transaminitis, which managed conservatively N-acetylcystein...
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