INTRODUCTION Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion increases oxygen (O2) delivery but rarely improves tissue O2 uptake in patients with sepsis. Possible causes include RBC alterations due to prolonged storage or residual leukocyte-derived inflammatory mediators. The aim of this study was to compare the effects of two types of trans...

BACKGROUND Allogeneic red blood cell transfusion is associated with increased morbidity and mortality in adult trauma patients. Although studies have suggested that the adoption of a more restrictive transfusion strategy may be safely applied to critically ill adult and all-cause critically ill pediatric patients, recent developments in our understanding of the negative consequences of red bloo...

Madam, Transfusion of blood products is a life rescuing medical intermediation; however, associated adverse transfusion reactions are major pitfalls. Transfusion-associated circulatory overload (TACO) life-threatening pulmonary oedema that develops secondary to volume overload. Underlying precipitating factors include ages >60 years or <3 years, low body mass index (BMI), rapid rate and p...

BACKGROUND Fetal bilirubin is routinely measured at our center when taking a pretransfusion blood sample intrauterine transfusions in hemolytic disease of the fetus and newborn. However, clinical value fetal assessment not well known, information rarely used. We speculated that there could be role for this measurement predicting need neonatal exchange transfusion. OBJECTIVE This study aimed to ...

OBJECTIVES The shock index (SI) and its derivations, the modified shock index (MSI) and the age shock index (Age SI), have been used to identify trauma patients with unstable hemodynamic status. The aim of this study was to evaluate their use in predicting the requirement for massive transfusion (MT) in trauma patients upon arrival at the hospital. PARTICIPANTS A patient receiving transfusion...

OBJECTIVE The purpose of this article is to describe the clinical symptoms and illustrate the radiological manifestations of transfusion-related acute lung injury (TRALI) as the condition develops. We mention those findings that aid the discrimination from transfusion-associated cardiac overload. We will also point some of the characteristics that increase the risk of TRALI. CONCLUSION TRALI ...

Mr Corazon is a 78-year-old man with insulin-dependent diabetes mellitus and an ejection fraction of 40% who is postoperative day 2 from coronary artery bypass grafting. He has been extubated and feels good, but he remains on a low-dose epinephrine infusion to support his blood pressure. His cardiac index is 2.2 L/m, and he has a mixed venous oxygen saturation of 59%. He has low filling pressur...

OBJECTIVE The literature is inconsistent regarding the role of chronic obstructive pulmonary disease (COPD) as a risk factor for blood product transfusion during coronary artery bypass graft (CABG). One reason may be lack of objective criteria to define COPD in previously published reports. We examined the role of COPD as a risk factor for transfusion using a strict definition based on objectiv...

INTRODUCTION The aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in critically ill patients using near-infrared spectroscopy (NIRS) technology. METHODS This prospective, observational study included 44 consecutive patients hospitalized in the 31-bed, medical-surgical intensive care ...

Despite the use of HLA-matched platelets for alloimmunized recipients, transfusion failures occur. In order to reduce these failures, we investigated the use of a radiolabeled antiglobulin technique for platelet crossmatching. The principle of the test is that of an indirect Coombs test using 125I labeled goat anti-human IgG. Incompatibility is determined by calculating a radioactivity antiglob...