Our ability to modify whole animal genetics has grown considerably in the last two decades. We have seen concerns regarding food safety and protection of breeding rights of genetically modified animals compel redirection of genetic engineering experimentation toward biomedical applications. Indeed, it has been nearly twenty years since the first transgenic livestock appeared in the literature, ...

Background DOX is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. However, its cardiac toxicity limits the clinical usefulness of this drug. Previous reports have shown Corticosteroids induce a cytoprotective effect on cardiomyocytes. Mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for a...

background dox is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. however, its cardiac toxicity limits the clinical usefulness of this drug. previous reports have shown corticosteroids induce a cytoprotective effect on cardiomyocytes. mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for as...

Introduction: Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which has much benefited from animal models to find the basics of its pathophysiology. In our previous work (Haghani, Shabani, Javan, Motamedi, & Janahmadi, 2012), a non-transgenic rat model of AD was used in electrophysiological studies. However, we did not investigate the histological aspects in the ...

introduction: helicobacter pylori (h. pylori) is a gastric pathogen of primates and causes active chronic gastritis as well as peptic ulcers. a wide range of studies is in effect to prevent or cure helicobacter infection and thus its associated disorders. in order to test various drug regimens as well as potential vaccines against h. pylori infection, a suitable animal model is required which s...

purpose: the purpose of this study is to model cryptosporidiosis in laboratory animals. the parasites were inoculated into animalsand thenmultiplied. the process of proliferation was compared to controlcryptosporidiosis in humans. materials and methods: twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category i while the categor...

background: leishmaniasis is a worldwide disease prevalent in tropical and sub- tropical countries. in the present study the immunogenicity of three human hla-dr1 restricted peptides derived from l. major gp63 protein was evaluated using fvb/n-dr1 transgenic mouse model. methods: the immunity generated by three mhc class ii – restricted peptides with the sequence of aarlvrlaaagaavt (aar), aaplv...

Canines are considered the most authentic model for studying multifactorial human diseases, as these animals typically share a common environment with man. Somatic cell nuclear transfer (SCNT) technology along with genetic engineering of nuclear donor cells provides a unique opportunity for examining human diseases using transgenic canines. In the present study, we generated transgenic canines ...

Animal models of gestational hypertension are problematic. A novel mouse model was described earlier. The dams in that study were transgenic for human angiotensinogen and the sires for human renin; human renin was expressed in and produced by the placenta. This model was adapted to the rat, which has greater utility in terms of chronic instrumentation and physiologic measurements. Female rats t...