نتایج جستجو برای: transgenic mouse
تعداد نتایج: 324509 فیلتر نتایج به سال:
This study aimed to establish a transgenic mouse model of corneal dystrophy (CD) overexpressing the human transforming growth factor, β-induced, 68 kDa (TGFBI, also known as BIGH3) gene. A purified and linearized recombinant plasmid carrying the expression cassette BIGH3‑IRES‑EGFP was microinjected into the pronuclei of C57BL/6J mouse fertilized eggs under the control of the phosphoglycerate ki...
The mouse spot test, an in vivo mutation assay, has been used to assess a number of chemicals. It is at present the only in vivo mammalian test system capable of detecting somatic gene mutations according to OECD guidelines (OECD guideline 484). It is however rather insensitive, animal consuming and expensive type of test. More recently several assays using transgenic animals have been develope...
Astrocytes are a diverse and morphologically complex class of glial cells restricted to the central nervous system which have been implicated in modulation neuronal activity. The cerebellum is involved planning movements motor learning. Within three deep cerebellar nuclei (dentate, interposed fastigial) provide sole output. fastigial nucleus participates saccadic vestibular function, recent evi...
Although rats are preferred over mice as an animal model, transgenic animals are generated predominantly using mouse embryos. There are limitations in the generation of transgenic rat by embryo manipulation. Unlike mouse embryos, most of the rat embryos do not survive after male pronuclear DNA injection which reduces the efficiency of generation of transgenic rat by this method. More importantl...
Studies on the therapeutic potential of adult stem cells in the G93A animal model of amyotrophic lateral sclerosis (ALS) Dissertation Submitted in partial fulfillment of the requirements for the degree Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). Behav Brain Res 213:82-87. Intraspinal injection of human umbilical cord blood-derived cells ...
Setting up breeding programs for transgenic mouse strains require to distinguish homozygous from the heterozygous transgenic animals. The combinational use of the fluorescence reporter transgene and small animal in-vivo imaging system might allow us to rapidly and visually determine the transgenic mice homozygous for transgene(s) by the in vivo fluorescence imaging. RLG, RCLG or Rm17LG transgen...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید