The human fungal pathogen Candida albicans undergoes white-opaque phenotypic switching, which enhances its adaptation to host niches. Switching is controlled by a transcriptional regulatory network of interlocking feedback loops acting on the transcription of WOR1, the master regulator of white-opaque switching, but regulation of the network on the translational level is not yet explored. Here,...

background: diabetic retinopathy is the major cause of blindness among working-age population across the world. despite the urgent need for research strategic planning in this field, no systematic research has been previously performed analyzing the published research on diabetic retinopathy. the study aimed to analyze the scientific productions on dr for drawing a general roadmap for future re...

Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this s...

Michele Donato, Zhonghui Xu, Alin Tomoiaga, James G. Granneman, Robert G. MacKenzie, Riyue Bao, Nandor Gabor Than, Peter H. Westfall, Roberto Romero, Sorin Draghici1,7∗ Computer Science Department, Wayne State University Perinatology Research Branch, NICHD/NIH Center for Advanced Analytics and Business Intelligence, Texas Tech University Center for Integrative Metabolic and Endocrine Research, ...

the rapid melting of a semi- infinite body due to the absorption of a cw laser beam radiation has been studied. the enthalpy technique for the solution of phase change problems has been used in an explicit finite difference form to calculate the transient temperature distribution in the semi-infinite body and the growth rate of the melt pool. the technique has been modified so that it is not ne...

The University of Hawai‘i (UH) at Manoa, John A. Burns School of Medicine received a research infrastructure award in November 2010 to advance clinical and translational research in health disparities reduction in Hawai‘i. Clinical and translational research refers to the translation of knowledge from the laboratory bench to the patient’s bedside and then to the larger community. The grant was ...