Neurons demand vast and vacillating supplies of energy. As the key contributors of this energy, as well as primary pools of calcium and signaling molecules, mitochondria must be where the neuron needs them, when the neuron needs them. The unique architecture and length of neurons, however, make them a complex system for mitochondria to navigate. To add to this difficulty, mitochondria are synth...

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Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry. Translational aspects with clinical questions are the focus in academia...

conclusion mature biofilms were found to be much more resistant to antifungal agents and the host immune system than free cells. the factors responsible for high resistance included the complex architecture of biofilms, ecm, increased expression of drug efflux pumps, and metabolic plasticity. objectives the present work investigated certain aspects of the resistance of c. albicans biofilms to d...

Video transmission over the Internet is becoming very popular with the majority of applications transporting stored pre-encoded video from server to client. These new applications have strict timing and loss requirements, which the current deployment of the Internet is unable to guarantee. To enable quality streaming of real time video, the application has to be rate adaptive and use feedback s...

using a hierarchical hybrid fuzzy model, this paper presents an intelligent system to manage the traffic of ambulances and the vehicles for transporting blood and blood products and generally the transportation related to health emergencies. the transportation of emergency patients, emergency accidents and health-related emergencies, and the transportation of blood and blood products should be ...