Gender identity disorder is an urgent sense of discomfort and inappropriateness of the sexual anatomy and urgent desire to get rid of genital organs and to live as a person of the opposite sex. The importance of studying gender identity disorder and its negative impact on the living conditions of suffering people, was laying the groundwork to do some research in terms of psychology and sociolog...

Estimado Editor, escribimos como coautores de las Guías de práctica clínica para la valoración y tratamiento de la transexualidad, del Grupo de Trabajo de Identidad y Diferenciación Sexual de la Sociedad Española de Endocrinología y Nutrición (GIDSEEN)1. El tratamiento hormonal cruzado estándar para los transexuales adultos con hormonas del sexo opuesto y el enfoque, cada vez más común, de la s...

No-one, wrote Frank Beach, a notable contributor to the experimental study of hormones and sexual behaviour, ever died from lack of sex. But the personal, social and legal aspects of sexual behaviour are a pervasive pre-occupation in all humans. The variety and vagaries of sex can have severe implications, and the existence of homosexuality and disorders of gender identity demand some sort of e...

Transsexuality is an individual's unshakable conviction of belonging to the opposite sex, resulting in a request for sex-reassignment surgery. We have shown previously that the bed nucleus of the stria terminalis (BSTc) is female in size and neuron number in male-to-female transsexual people. In the present study we investigated the hypothalamic uncinate nucleus, which is composed of two subnuc...

word count: 249 / max 250) Context. Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex differences in kisspeptin expression have been shown in humans in adulthood, the developmental origin of this sex difference o is unknown. Objectives. Our objectives were...

n Eleven post-operative male-to-female transsexuals were exposed to sexual stimuli on video while physiological (vaginal photoplethysmographic) and subjective measures of sexual arousal were being recorded. The comparison of their responses to male versus female stimuli, combined with their orientations (attracted to men versus women), illustrated a target specific pattern of sexual arousal acr...

On July 11, in Christine Goodwin v. United Kingdom (Application No. 28957/95) and I. v. United Kingdom (Application No. 25680/94), a Grand Chamber of 17 judges of the European Court of Human Rights held unanimously that the United Kingdom’s refusal to permit post-operative transsexuals to have their birth certificates amended to reflect their reassigned sex, and to contract different-sex marria...