The TBP-related factor TRF binds to a TATA box promoter sequence and mediates basal transcription in vitro. A central question is: does TRF function in vivo to transduce the effects of activators in a tissue-specific fashion?

CRUDE ETHANOLIC EXTRACT OF THUJA OCCIDENTALIS (FAM: Cupressaceae) is used as homeopathic mother tincture (TOΦ) to treat various ailments, particularly moles and tumors, and also used in various other systems of traditional medicine. Anti-proliferative and apoptosis-inducing properties of TOΦ and the thujone-rich fraction (TRF) separated from it have been evaluated for their possible anti-cancer...

BACKGROUND Beta(2)-transferrin (beta-2 trf) is a desialated isoform of transferrin found only in cerebrospinal fluid (CSF), ocular fluids, and perilymph. In aural, nasal, and wound drainages, this protein is an important marker of CSF leakage. Immunofixation electrophoresis (IFE) on agarose gels is a widely accepted qualitative technique for detection of small amounts of beta-2 trf, but disadva...

Vitamin E is an established antioxidant. However, the effect of vitamin on healthspan, which deteriorates during ageing, has not been determined because most related studies have emphasized its effects lifespan. Therefore, purpose this study was to determine palm tocotrienol-rich fraction (TRF) lifespan, locomotion and thermotolerance Caenorhabditis elegans, share many common gene sequences wit...

Terminal Restriction Fragment (TRF) patterns, also known as Terminal Restriction Fragment Length Polymorphisms (T-RFLP), are a recently introduced PCR-based tool for studying microbial community structure and dynamics. Since the first review of TRF methodology (Marsh, 1999. Curr. Op. Microbiol. 2: 323-7), at least 35 new research articles were published that include this powerful tool in some p...

Tocotrienols, isomers of vitamin E, have been found to possess many health benefits. The present study was designed to determine whether tocotrienol has a direct cardioprotective role. Isolated rat hearts were perfused for 15 min with Krebs-Ringer bicarbonate buffer in the absence or presence of palm tocotrienol derived from the tocotrienol-rich fraction (0.035%) of palm oil (TRF). In another g...

Genomic DNA sequence is very abundant in periodic patterns, which play important biological roles, such as gene expression, genome structural stabilization, and recombination. Tandem repeat is a type of periodic patterns and concerns several genetic diseases. Tandem repeat finder (TRF) [1] is one of the widely used programs to find tandem repeats without a priori knowledge. Statistical models a...

TRF(Thyrotrophin-Releasing-Factor) is produced in the anterior hypothalamus, deposited in the neurohypophysis, and then passed into the cerebrospinal fluid and the blood stream to be excreted into urine(Shibusawa et al., 1959c). It has been demonstrated neither in the median and posterior hypothalamus, nor in other tissues, and body fluids. It is an hitherto unknown hormone which controls the t...

Abstract Background tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown that tRFs associated Argonaute (AGO) complexes and inhibit gene expression the same manner as miRNAs. However, there currently no tools for accurately predicting tRF targe...

BACKGROUND Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months. METHODS Sixty-two subjects were recruited from two age gro...