A síntese, a caracterização espectroscópica e os resultados biológicos de novas séries de 2-(4-piridil)-1,2,3,4-tetrahidroquinolinas e seus precursores, -N-aril-N-[1-(4-piridil)but-3-enil] aminas, são descritos. Foi encontrado que ambos, precursores substituídos g-piridil e os produtos finais, as tetrahidroquinolinas, demonstraram excelentes atividades antifúngicas contra Aspergillus fumigatus,...

The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, al...

Antifungal activities of clove essential oil and its volatile vapour against dermatophytic fungi including Candida albicans, Epidermophyton floccosum. Microsporum audouinii, Trichophyton mentagrophytes, and Trichophyton rubrum were investigated. Both clove essential oil and its volatile vapour strongly inhibit spore germination and mycelial growth of the dermatophytic fungi tested. The volatile...

1 Senior Resident, 2 Assistant Professor Department of Microbiology DRPGMC Tanda. Abstract Dermatophytosis is a superficial fungal infection confined to the stratum corneum and appendages of the skin. Health education, timely diagnosis and treatment has brought down the fungal infection rate in developed countries but it is still common in developing countries. Tinea corporis refers to all the ...

objective(s): trichophyton rubrum (t. rubrum) is one of the most common dermatophytes worldwide. this fungus invaded skin appendages of humans and animals. recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. besides, using some plant extracts have been indicated in herbal medicine as an alternative tre...

Trichophyton rubrum, an anthropophilic and cosmopolitan fungus, is the most common agent of superficial mycoses. In this study, T. rubrum infection was modelled by adding human skin sections to a limited medium containing glucose and cDNA microarrays were used to monitor T. rubrum gene expression patterns on a global level. We observed that exposure to human skin resulted in upregulation of the...

The main etiological agents in dermatophytosis of human skin and nails are Trichophyton, particular Trichophyton rubrum (T. rubrum) mentagrophytes mentagrophytes). A new series twenty-three 3- 4-arylcoumarins was synthesized the antifungal activities against clinical isolates T. were evaluated. Sixteen out molecules exhibited activity one or both fungi strains. In some cases, has been comparabl...

OBJECTIVE To evaluate the prevalence of tinea capitis, tinea pedis, and tinea unguium in children from several schools of Barcelona city. METHODS During the period of 2003-2004, a prospective cross-sectional study was carried out in 1,305 children (9% immigrant population) between the ages 3 and 15 in 17 schools in Barcelona. A systematic examination of the feet, (including nails and scalp), ...

Les infections mycosiques du pied constituent un motif fréquent de consultation chez les diabétiques, le diabète constituant à la fois un facteur favorisant et aggravant les lésions cutanéomuqueuses. L'objectif de ce travail était d'identifier la flore mycologique locale responsable des lésions du pied chez le diabétique et déterminer les facteurs favorisant la survenue de mycoses. Il s'agissai...

A total of 92 clinical isolates of dermatophytes (52 of Trichophyton rubrum and 40 of Trichophyton mentagrophytes) were selected for testing with six antifungal drugs (terbinafine, griseofulvin, clotrimazole, miconazole, isoconazole, and fluconazole) and two pairs of drug combinations (ketoconazole-cyclopiroxolamine and itraconazole-cyclopiroxolamine). Two methods of inoculum preparation for su...