We show that Trichostatin A (TSA)-induced partial histone hyperacetylation causes a unidirectional shift in the position of a previously defined binding domain for the centromere-specific histone H3 homologue CENP-A at a human neocentromere. The shift of approximately 320 kb is fully reversible when TSA is removed, but is accompanied by an apparent reduction in the density of CENP-A per unit le...

Increased levels of pup licking/grooming and arched-back nursing by rat mothers over the first week of life alter the epigenome at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. Differences in the DNA methylation pattern between the offspring of High and Low licking/grooming--arched-back mothers emerge over the first week of life, are reversed with cross-fostering,...

Various oncogenes correlate with tumor phenotypes, which represent transformed morphology, loss of contact inhibition, colony formation in soft agar and tumorigenicity in nude mice. Thus, inducers of phenotypic reversion in oncogene-transformed cells mayact as selective antitumor agents without cytotoxicity. Our screening for such substances resulted in the isolation of trichostatin D (Fig. 1),...