Abstract The transition-metal-free total syntheses of the oxygenated carbazole natural products glycoborine, carbazomycin A and B are reported. key step involves an NBS-mediated cyclobutanol ring expansion to 4-tetralones for preparation tricyclic core.

Transporter proteins bind ions and small molecules and transfer them across lipid membranes. Recent studies on transporters, discussed in this issue's Biochemistry Select, provide insight into the family of proteins targeted by tricyclic antidepressants. Other work sheds light on glucose absorption in the gut, host-pathogen interactions , and a mechanism used by an important food crop to adapt ...

Site-saturated substitution in Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase at Ile705 position produced three chair-boat-chair (C-B-C) truncated tricyclic compounds, two 17α-exocyclic protosteryl intermediates, two protosteryl C-17 truncated rearranged intermediates and the normal biosynthetic product, lanosterol. These results indicated the importance of the Ile705 residue in affe...

The distribution of acyclic and cyclic biphytanediols, which are the putative breakdown products of glycerol dialkyl glycerol tetraethers (GDGTs), was investigated for recent marine sediments from Nankai Trough, offshore Kii Peninsula. The most abundant diol is tricyclic biphytanediol of which relative abundance is in the range from 32 to 46%. The carbon skeleton of the detected tricyclic biphy...

Venlafaxine is a novel, non-tricyclic antidepressant. Venlafaxine imparts its antidepressant effects by inhibiting the neuronal uptake of norepinephrine, serotonin and to a lesser extent, dopamine1. It lacks monoamine oxidase activity and, more importantly, lacks the adverse effect profile of tricyclic antidepressants. Now, there has been the sustained-release preparation of this drug coming in...