Change of chirality of the first N-terminal amino acid of tripeptides VFF and FFV from l to d results in self-assembled hydrogels at physiological pH from non-assembling l-analogues. Interestingly, changing the chirality of F yields very different nanostructures; nanotapes are observed for (D)VFF, twisted fibers for (D)FFV.

Amphiphilic tripeptides catalyze conjugate addition reactions of aldehydes to nitroolefins in water with high yields and stereoselectivities. The amphiphilic nature shields the peptidic catalyst from the water and stabilizes the emulsion formed by the reactants in the aqueous environment. The findings have intriguing implications for the chemical evolution of enzymes.

Transport of natural peptides and antibacterial phosphonopeptide analogues was studied in Streptococcus faecalis ATCC 9790. Competition studies, and the isolation of peptide-transport deficient mutants, indicate the presence of two peptide permeases. One is a high-rate system used by dipeptides, and to a lesser extent tripeptides; the other is a low-rate oligopeptide system. Following uptake, p...

Gold(Ill) is isoelectronic (5d8) and often isostructuml (square-planar) with Pt(ll) and might form the basis of active anticancer agents [1]. However little is known about the biochemistry of Au(lll), a subject also of interest in connection with the side-effects of antiarthritic gold drugs [2]. In this work we have explored the binding of [Au(lll)(diethylenetriamine)CI]CI2 to tripeptides over ...

Simple unmodified N-proline-based di- and tripeptides in combination with sodium hydroxide additive catalyze the asymmetric Michael reaction of ketones with nitroolefins to furnish the corresponding gamma-nitroketones with up to 99% yield, 99:1 dr and 70% ee at room temperature and on water without any organic cosolvent.

In this study, we show that the dppBCDF operon of Pseudomonas aeruginosa PA14 encodes an ABC transporter responsible for the utilization of di/tripeptides. The substrate specificity of ABC transporters is determined by its associated substrate-binding proteins (SBPs). Whereas in E. coli only one protein, DppA, determines the specificity of the transporter, five orthologous SBPs, DppA1-A5 are pr...

PURPOSE To identify and synthesize the polymorphonuclear leukocyte chemoattractant(s) released from alkali-degraded corneas. METHODS Corneas were degraded in 1.0 N NaOH, neutralized, ultrafiltered, and dialyzed. The final active ultrafiltrate was subjected to high-performance liquid chromatography on a Protein PAK I-60 column. The most active fractions were further separated on a mu-Bondapak-...

The development of catalytic tools for the late-stage modification amino acids within a peptide framework is challenging task capital importance. Herein, we report Ru-catalyzed C(sp2)?H hydroxylation collection Tyr-containing di- and tripeptides featuring use carbamate as removable directing group PhI(OCOCF3)2 (PIFA) oxidant. This air-compatible tagging technique reliable, scalable provides acc...