In nuclear power plants (NPPs), digital I&C systems are expected to lead to increasing level of safety and improved performance in communication, maintenance, and signal processing. They are expected to be used in all new NPP designs, while existing NPPs are being evaluated for the switch from analog to digital control systems. Switching from analog to digital or working with hybrid systems has...

BACKGROUND Thy-1.1 transgenic mice develop hypercellular focal and segmental glomerulosclerosis (FSGS) lesions that mimic human collapsing FSGS, in 7 days after injection with anti-Thy-1.1 antibodies. These lesions consist of proliferating parietal epithelial cells (PECs). We questioned whether the angiotensin converting enzyme inhibitor (ACE), captopril, could prevent the development of FSGS a...

BACKGROUND New antitumor therapeutic strategies aim to combine different approaches that are able to induce tumor-specific effector and memory T cell responses that might control tumor growth. Dendritic cells (DCs) have the capacity to induce antigen-specific cytotoxic T lymphocytes. We have previously shown that the combined treatment of paclitaxel chemotherapy (Chemo) and injection of DCs led...

In antiviral therapy of hepatitis B virus (HBV) infection, drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs (NAs). Primary resistance mutation (rtM204V) contributes to lamivudine (LAM)-resistance, and compensatory mutations (rtL180M and rtV173L) restore viral fitness and increase replication efficiency. The evaluation of new anti-viral agents aga...

PURPOSE To evaluate the visual and anatomical outcomes for neovascular age-related macular degeneration with submacular hemorrhage after intravitreal injections of tenecteplase (TNK), anti-vascular endothelial growth factor (VEGF) and expansile gas. METHODS This study was a retrospective clinical case series following 25 eyes of 25 patients. All patients received a triple injection using 0.05...

Although clinical end points remain the definitive measure of therapeutic efficacy in multiple sclerosis, more sensitive markers of disease activity are required to screen potential disease-modifying agents. The use of gadolinium contrast-media in MRI studies increases both the reliability and sensitivity of detecting active lesions in multiple sclerosis. We studied three potential methods for ...

Knowledge-Enhanced Pre-trained Language Models (KEPLMs) are pre-trained models with relation triples injecting from knowledge graphs to improve language understanding abilities.Experiments show that our model outperforms other KEPLMs significantly over zero-shot probing tasks and multiple knowledge-aware tasks. To guarantee effective injection, previous studies integrate encoders for representi...

Retropharyngeal abscess is a rare but serious infection, in children, it often secondary to upper respiratory tract infections.We report the case of an 18-month-old infant admitted emergencies for acute febrile torticolis. A computed tomographic (CT) scan with contrast agent injection revealed collection retropharyngeal space; management consisted triple antibiotic therapy and transoral drainag...

Myelin inhibitors, including MAG, are major impediments to CNS regeneration. However, CNS axons of DRGs regenerate if the peripheral branch of these neurons is lesioned first. We show that 1 day post-peripheral-lesion, DRG-cAMP levels triple and MAG/myelin no longer inhibit growth, an effect that is PKA dependent. By 1 week post-lesion, DRG-cAMP returns to control, but growth on MAG/myelin impr...