نتایج جستجو برای: triple negative
تعداد نتایج: 572352 فیلتر نتایج به سال:
Abstract Purpose of Review Triple-negative breast cancer (TNBC) represents about 15–20% all cancers and often presents as an aggressive with poor prognosis compared to other forms cancer. This article will review the clinical manifestations, imaging features, pathology correlation, treatment management, TNBC. Recent Findings While mammography ultrasound can be used diagnose TNBC, MRI is most ac...
Little is known about the etiologic profile of triplenegative breast cancer (negative for estrogen receptor/ progesterone receptor/human epidermal growth factor), a breast cancer subtype associated with high mortality and inadequate therapeutic options. We undertook this study to assess the risk for triple-negative breast cancer among women 45 years of age and younger in relation to demographic...
OBJECTIVE Despite the clinical similarities triple-negative and basal-like breast cancer are not synonymous. Indeed, not all basal-like cancers are negative for estrogen receptor, progesterone receptor and HER2 expression while triple-negative also encompasses other cancer types. P53 protein appears heterogeneously expressed in triple-negative breast cancers, suggesting that it may be associate...
W boson pair production processes at e^{+}e^{-} and pp colliders have been conventionally interpreted as measurements of WWZ and WWγ triple gauge couplings (TGCs). Such an interpretation is based on the assumption that new physics effects other than anomalous TGCs are negligible. While this "TGC dominance assumption" was well motivated and useful at LEP2 thanks to precision electroweak constrai...
Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.
Activation of the EGFR, KRAS, and ALK oncogenes defines 3 different pathways of molecular pathogenesis in lung adenocarcinoma. However, many tumors lack activation of any pathway (triple-negative lung adenocarcinomas) posing a challenge for prognosis and treatment. Here, we report an extensive genome-wide expression profiling of 226 primary human stage I-II lung adenocarcinomas that elucidates ...
BACKGROUND Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease spe...
Take home messages The majority of basal-like breast cancers have a triple negative phenotype and the vast majority of triple negative cancers display a basal-like transcriptome, however the two are not synonymous. Basal-like and triple negative breast cancers comprise a heterogeneous group of diseases, which are characterised by a constellation of morphological features. Not all basal-like and...
BACKGROUND Breast cancer in Iranian women occurs about a decade earlier than in Western countries. This study sought to evaluate the impact of triple negative phenotype on early onset of ductal cell breast cancer and its prognosis in Iranian females. METHODS Estrogen and progesterone receptors, Her-2 overexpression and nuclear accumulation of P53 were assessed in sixty surgically resected for...
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