An efficient and transition-metal-free approach was developed to access a series of fluorinated heteroaromatics in moderate to excellent yields. This one-pot procedure features a triple-relay transformation of rapid dearomatization, fluorination, and rearomatization processes, which represents a conceptually novel strategy of combining partial hydrogenation and electrophilic fluorination.

The work described here aims to create a wordnet automatically from a semantic network based on terms. So, a clustering procedure is ran over a synonymy network, in order to obtain synsets. Then, the term arguments of each relational triple are assigned to the latter, originating a wordnet. Experiments towards our goal are reported and their results validated.

The loss of the corneal endothelial cells, especially in a first postoperative year, has been observed in patients who underwent penetrating keratoplasty (PK). The implantation of new generation of "iris claw" phakic IOL (Verisyse) in refractive cases has been shown to cause clinicaly insignificant endothelial cell loss. In our prospective case series we investigated the endothelial cell loss a...

Abstract Introduction Neoadjuvant chemotherapy (NACT) has been established in down-staging tumours, allowing breast conserving surgery. Additionally, NACT informs treatment decisions guided by tumour response. Pathological complete response (pCR) correlates with disease-free survival. It is known that rates vary according to biological subtype. This retrospective analysis aimed analyse the rate...

The static and analytic scheduling approach is very difficult to follow and is not always applicable in real-time. Most of the scheduling algorithms are designed to be established in offline environment. However, we are challenged with three characteristics in real cases: First, problem data of jobs are not known in advance. Second, most of the shop’s parameters tend to be stochastic. Third, th...

BACKGROUND Accessory navicular can become symptomatic in childhood, and in some cases, the condition is associated with progressive flattening of the longitudinal arch. Moreover, some severe, rigid flatfoot deformities are associated with an accessory navicular. We investigated the results of concomitant calcaneo-cuboid-cuneiform osteotomies (triple C) and the modified Kidner procedure for seve...

OBJECTIVES To evaluate whether a triple dose of gadolinium-DTPA (Gd-DTPA) or delayed MRI increase the number, size, and conspicuousness of enhancing lesions in patients with benign multiple sclerosis. METHODS T1 weighted brain MRI was carried out on 20 patients with benign multiple sclerosis (expanded disability status scale < 3 with a disease duration > 10 years) in two sessions. In the firs...

objective(s): adeno-associated virus type 2 (aav2) vectors are widely used for both experimental and clinical gene therapy. a recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. in this study, a fast and simple method is presented to generate aav2 vector helper plasmids encodin...

  Objective(s): Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast and simple method is presented to generate AAV2 vector helper plasmids encod...