Motonic dystrophy and fragile X syndrome are two genetically determined relatively common disabilities. Both are examples of a new type of mutation mechanism called unstable or dynamic mutations, triple repeats expansions or DNA amplification. Fragile X syndrome is recognized as the main cause of hereditary mental retardation and myotonic dystrophy is considered the most common muscular dystrop...

BACKGROUND Triple-A syndrome (Allgrove syndrome) is an autosomal recessive disorder characterized by adrenal insufficiency, alacrima, achalasia, and - occasionally - autonomic instability. Mutations have been found in the AAAS gene on 12q13. CASE PRESENTATION We present the case of a 12 year-old boy with classic systemic features of triple-A syndrome and several prominent ophthalmic features,...

Let G be a finite group and let T1 denote the number of times a triple (x, y, z) ∈ G3 binds X, where X = {xyz, xzy, yxz, yzx, zxy, zyx}, to one conjugacy class. Let T2 denote the number of times a triple in G3 breaks X into two conjugacy classes. We have established the following results: i) the probability that a triple (x, y, z) ∈ D3 n binds X to one conjugacy class is ≥ 58 . ii) for groups s...

Motivated by Schur-concavity, we introduce the notion of G-concavity where G is a closed subgroup of the orthogonal group O(V ) on a finite dimensional real inner product space V . The triple (V,G, F ) is an Eaton triple if F ⊂ V is a nonempty closed convex cone such that (A1) Gx ∩ F is nonempty for each x ∈ V . (A2) maxg∈G(x, gy) = (x, gy) for all x, y ∈ F . If W := spanF and H := {g|W : g ∈ G...

The aim of this study was to delineate the clinical and therapeutic characteristics of Pseudomonas aeruginosa bronchopulmonary infection in acquired immunodeficiency syndrome (AIDS) patients. Eighteen AIDS patients had 39 episodes of P. aeruginosa bronchopulmonary infection. Their mean CD4 cell count was 0.012+/-0.011 cells x 10(9) x L(-1) and two episodes (5.1%) occurred in neutropenic patient...

The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.

Kang, Q. and Y. Chang, Further results about large sets of disjoint Mendelsohn triple systems, Discrete Mathematics 118 (I 993) 2633268. In this note, a construction of the large sets of pairwise disjoint Mendelsohn triple systems of order 72k + 6, where k > 1 and k F 1 or 2 (mod 3), is given. Let X be a set of v elements (v 2 3). A cyclic triple from X is a collection of three pairs (x, y), (y...