The ability of the kidneys to excrete an acid urine is often assessed by correlating plasma carbon dioxide and urine pH. A low plasma CO2 should be accompanied by a low urine pH, provided that respiratory function is normal. Buchanan and Komrower (1958) consider that the renal excretion of hydrogen ions is normal in children if urine pH falls below 5 0, after a single dose of 0g./kg. of ammoniu...

A case of pancreatoblastoma arising in a five year old girl was analysed using histochemical and immunohistochemical methods. The tumour was composed of tubular gland-like structures, squamoid components and some small round cells surrounding tubular structures. The cytoplasm of the small round cells and a few of the squamoid cells was positive on staining with Grimelius argyrophil stain. Immun...

During nephrogenesis, new nephrons are induced in the periphery of the kidney, while maturing nephrons occupy a deeper position in the renal cortex. This centrifugal pattern of maturation is characterized by nephron patterning, establishment of proximal-distal segment identity, tubular and glomerular growth and differentiation, and acquisition of specialized functions. All of these processes ar...

dear editor multiple choice tests are the most common objective tests in medical education which are used to assess the ind­ividual knowledge, recall, recognition and problem solving abilities. one of the testing components is the post-test analysis. this component includes; first, qualitative analysis of the taxonomy of questions based on the bloom’s educational objectives and percentage of th...

The kidney handles calcium by filtration and reabsorption. About 60% of the plasma calcium is filterable, and 99% is reabsorbed in the tubule. In the proximal tubule, the reabsorption is passive and paracellular, but in the distal tubule is active and transcellular. Thus, renal tubular cells are exposed to very high concentrations of calcium in both, the extracellular and the intracellular comp...

BACKGROUND & AIMS Mutations in Jagged1 , a Notch ligand, cause Alagille syndrome (AGS), a disorder characterized by a paucity of intrahepatic bile ducts (IHBD). The mechanism underlying the contribution of the Notch signaling pathway to IHBD formation, however, remains unknown. Here we investigated the role of Notch signaling in IHBD development. METHODS The expression patterns of Jagged1, No...

Transplantation of human kidney-derived cells is a potential therapeutic modality for promoting regeneration of diseased renal tissue. However, assays that determine the ability of candidate populations for renal cell therapy to undergo appropriate differentiation and morphogenesis are limited. We report here a rapid and humane assay for characterizing tubulogenic potency utilizing the well-est...

the current study conducted a finite element (fe) and experimental investigation on tubular channel angular pressing as a noble severe plastic deformation technique for producing ultrafine grained and nanostructure tubular components. to examine the effects of the tcap process on the strain distribution and deformation behavior, fe simulations were employed. the fe results demonstrated that equ...

The nature of microproteinuria in the early years of insulin-dependent diabetes was investigated in a cross sectional study of 80 children with insulin-dependent diabetes and 40 normal children. Urinary excretion of three low molecular weight proteins: alpha-1-microglobulin, beta-2-microglobulin and kappa light chains was used as an index of proximal renal tubular function. The first urine samp...