نتایج جستجو برای: tumor vaccines
تعداد نتایج: 475750 فیلتر نتایج به سال:
Background and aims Tumor cell vaccines are widely used as a potential therapeutic. Different approaches are currently being applied to kill tumor cell vaccines prior to injection to prevent outgrowth of metastasis at the site of injection. We and others have previously shown that the mode by which tumor cells die can have significant effects on anti-tumor specific immune responses. Here, we ha...
Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...
BACKGROUND Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance of HPV-associated lesions. OBJECTIVE To generate two therapeutic fusion DNA vaccines (o...
TIMOTHY P. MORAN: Characterization of Dendritic Cells Transduced with Venezuelan Equine Encephalitis Virus Replicon Particles as Therapeutic Cancer Vaccines (Under the direction of Jonathan S. Serody and Robert E. Johnston) Cancer vaccines seek to harness the specificity of T and B lymphocytes for reduction of tumor burden, as well as prevention of recurrent disease by establishing immunologica...
Peptide vaccination for cancer immunotherapy requires an ideal immune response induced by epitope peptides derived from tumor-associated antigens (TAA). Heparanase is broadly expressed in various advanced tumors. Accumulating evidence suggests that heparanase can serve as a universal TAA for tumor immunotherapy. However, due to the low immunogenicity of peptide vaccines, an ideal immune respons...
Dendritic cell (DC)-based vaccines have exhibited minimal effectiveness in treating established tumors, likely because of factors present in the tumor microenvironment. One such factor is transforming growth factor (TGF), a cytokine that is produced by numerous tumor types and has been demonstrated to impair DC functions in vitro. We have evaluated the effect of TGFon the immunostimulatory acti...
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