When released into the bloodstream, proinflammatory cytokines have the ability to trigger the transcription of different genes in cells of the blood–brain barrier (BBB), including members of the nuclear factor kappa B (NF-kB) family and cyclooxygenase-2 (COX-2), the limiting enzyme for the formation of prostaglandins (PGs). The present study investigated the possibility that interleukin-1b (IL-...
