BACKGROUND The use of unrelated umbilical cord blood (UCB) has grown as an allogeneic source of hematopoietic cells for transplantation of patients with hematologic malignancies. As the number of UCB transplantation procedures has grown, an increasing number of publications have focused on disease-specific outcomes. METHODS This review focuses on the outcome data following UCB transplantation...

Reported in 1989, studies by Broxmeyer, Gluckman, and colleagues demonstrated that umbilical cord blood (UCB) is a rich source of hematopoietic stem/progenitor cells (HSPC) and that UCB could be used in clinical settings for hematopoietic cell transplantation. Since then, a great interest has been generated on the biological characterization of these cells. Over the last nine years, several gro...

Dear Sir, Umbilical cord blood (UCB) is a recognised and frequently used source of stem cells for allogeneic hematopoietic transplantation, not only for leukemias and lymphomas but also for bone marrow failure syndromes, haemoglobinopathies, immunodeficiencies and inborn errors of metabolism (Chen et al., 2013). Numerous studies have found the outcome after UCB transplantation to be as good as,...

The cellular and molecular mechanisms underlying the blunted allo-responsiveness of umbilical cord blood (UCB) T cells have not been fully elucidated. Protein expression of NFATc2 (nuclear factor of activated T cells c2), a critical transcription factor necessary for up-regulation of multiple cytokines known to amplify Tcell allogeneic responses, is reduced in UCB T cells. Affymetrix oligonucle...

We propose a novel variant of the UCB algorithm (referred to as Efficient-UCB-Variance (EUCBV)) for minimizing cumulative regret in the stochastic multi-armed bandit (MAB) setting. EUCBV incorporates the arm elimination strategy proposed in UCB-Improved (Auer and Ortner, 2010), while taking into account the variance estimates to compute the arms’ confidence bounds, similar to UCBV (Audibert, Mu...

1Castelo Branco University (UCB), Laboratory of Human Motricity Biosciences (LABIMH), Rio de Janeiro, Brazil; 2Castelo Branco University (UCB), Laboratory of Human Motricity Biosciences (LABIMH), Rio de Janeiro, Brazil; 3Estácio de Sá University (UNESA), Rio de Janeiro, Brazil; 4National Institute of Cancer (INCA), Rio de Janeiro, Brazil; 5Castelo Branco University (UCB), Laboratory of Human Mo...

2.4 Principal Investigators: Professor David Auslander, Department of Mechanical Engineering, U.C. Berkeley (UCB) Professor David Culler, Department of Electrical Engineering, U.C. Berkeley (UCB) Professor Paul K. Wright, Director, Center for Information Technology Research in the Interest of Society (CITRIS) and the Department of Mechanical Engineering, U.C. Berkeley (UCB) Dr. Yan Lu, Siemens ...

Submit Manuscript | http://medcraveonline.com Abbreviations: UCB-SCs: Umbilical Cord Blood-Derived Stem Cells; HSCs: Hematopoietic Stem Cells; MSCs: Mesenchymal Stem Cells; UCB-MSCs: Umbilical Cord Blood-derived Mesenchymal Stem Cells; UCB-MSCs: Umbilical Cord Blood-derived MSCs; hUCB-MSCs: Human Umbilical Cord Blood-derived MSCs; GvHD: Graft-versus-Host Disease; HIV: Human Immunodeficiency Virus.

OBJECTIVE To investigate the correlation between ultrasound measured placental volume and collected umbilical cord blood (UCB) volume in term pregnancy. MATERIAL AND METHODS An observational cross-sectional study of term singleton pregnant women in the labor ward at Maha Chakri Sirindhorn Medical Center was conducted. Placental thickness, height, and width were measured using two-dimensional ...

In the recent years, umbilical cord blood (UCB) has emerged as an alternative source of hematopoietic progenitors (CD34+) for allogeneic stem cell transplantation, mainly in patients lacking an HLA-matched marrow donor. Since 1998, about 2500 patients have received UCB transplants for a variety of malignant and non-malignant diseases. The vast majority of recipients were children with an averag...