INTRODUCTION Use of deep sequencing is becoming a critical tool in clinical virology, with an important impact in the HIV field for routine diagnostic purposes. Here, we present the comparison of deep and Sanger sequencing in newly diagnosed HIV patients, and the use of DeepChek v1.3 & VisibleChek for their interpretation and integration with virological and clinical data. PATIENTS AND METHOD...

BACKGROUND It is unknown whether HIV-positive patients experiencing virologic failure (VF) on boosted-PI (PI/r) regimens without drug resistant mutations (DRM) by standard genotyping harbor low-level PI resistant variants. CASTLE compared the efficacy of atazanavir/ritonavir (ATV/r) with lopinavir/ritonavir (LPV/r), each in combination with TVD in ARV-naïve subjects. OBJECTIVE To determine if...

Protracted, low-daily-dose T-ray exposure (3.8--7.5 cGy/day) segregates canines into separate survivaland pathology-based subgroups by the early elicitation of distinct, repair-mediated hemopathological response pathways. In this study, we verified the blood and marrow responses of two major subgroups prone to either aplastic anemia or myeloproliferative disease, along with two variants, and ex...

Context. Substructures – dark lanes and tails – of umbral dots (UDs) were predicted by numerical simulations of magnetoconvection and have been detected later in some observations. Aims. To provide constraints for realistic theoretical models of sunspot umbrae, we describe the observed properties and evolutionary characteristics of UDs (including their substructure) and of other umbral structur...

We present in this paper our three system submissions for the POS tagging subtask of the Empirist Shared Task: Our baseline system UdS-retrain extends a standard training dataset with in-domain training data; UdSdistributional and UdS-surface add two different ways of handling OOV words on top of the baseline system by using either distributional information or a combination of surface similari...

This manuscript describes the MatSWMM toolbox, an open-source Matlab, Python, and LabVIEW-based software package for the analysis and design of real-time control (RTC) strategies in urban drainage systems (UDS). MatSWMM includes control-oriented models of UDS, and the storm water management model (SWMM) of the US Environmental Protection Agency (EPA), as well as systematic-system edition functi...

Anthropogenic landscape change (i.e., disturbance) is recognized as an important factor in the decline and extirpation of wildlife populations. Understanding and monitoring the relationship between wildlife distribution and disturbance is necessary for effective conservation planning. Many studies consider disturbance as a covariate explaining wildlife behavior. However, we propose that there a...

down's syndrome (ds) is the most common chromosomal abnormality in human. subjects with ds are known to be peridisposed to develop leukemia. the molecular basis of the association between ds and leukemia is unknown. the unscheduled dna synthesis (uds) test measure the ability of dna-repair in mammalian cells after excision of a stretch of dna containing the region of damage induced by chem...

Since the capacity for DNA repair relative to other cellular processes is an important parameter relevant to mutagenesis, carcinogenesis, and also aging, its assessment should preferably be carried out in intact animals. For this reason we developed an autoradiographic technique for measuring DNA repair directly in vivo. By this method unscheduled DNA synthesis (UDS) can be detected quantitativ...

OBJECTIVES To track changes in the V3 env region of HIV-1 quasispecies and determine virus coreceptor use in cell reservoirs of patients on long-term suppressive antiretroviral therapy (ART). PATIENTS AND METHODS Ten patients whose plasma viraemia had been suppressed for a median of 5.5 years were followed for 5 years. The V3 env regions of viruses in peripheral blood mononuclear cells were a...