Ultrasound-mediated targeted drug delivery is a therapeutic modality under development with the potential to treat cancer. Its ability to produce local hyperthermia and cell poration through cavitation non-invasively makes it a candidate to trigger drug delivery. Hyperthermia offers greater potential for control, particularly with magnetic resonance imaging temperature measurement. However, cav...

This study proposes a new method to reconstruct three dimensional (3D) tongue surface motion during speech using only a few sections of the tongue measured with ultrasound imaging. Reconstruction of static 3D tongue surfaces has been reported. This is the first report for reconstruction of 3D tongue surface motion using ultrasound imaging. To temporally align data from multiple scan locations, ...

Freehand 3D ultrasound is particularly appropriate for the measurement of organ volumes. For small organs, which can be fully examined with a single sweep of the ultrasound probe, the results are known to be much more accurate than those using conventional 2D ultrasound. However, large or complex shaped organs are difficult to quantify in this manner because multiple sweeps are required to cove...

Histologic measurement of the thickness of melanoma is a major prognostic factor and governs the size of the surgical excision (1cm for melanomas less than 1 mm thick, 2 cm for melanomas thicker than 2 mm and 3 cm beyond 4 mm). To determine whether high-resolution ultrasound can be used to predict surgical margins and, thus, to operate on patients in a single procedure avoiding further re-excis...

PURPOSE: In scoliosis monitoring, tracked ultrasound has been explored as a safer imaging alternative to traditional radiography. The use of ultrasound in spinal curvature measurement requires identification of vertebral landmarks, but bones have reduced visibility in ultrasound imaging and high quality ultrasound machines are often expensive and not portable. In this work, we investigate the i...

Correct estimation of gestational age is essential for any study of ultrasound biometry and for everyday clinical practice. However, inconsistency in pregnancy dating may occur through differences in measurement methods or errors during measurement. In the INTERGROWTH-21(st) Project, pregnancies are dated by the last menstrual period, provided that it is certain and associated with a regular me...

In osteoporosis, changes in tissue structure and composition impair the mechanical strength of bone and increase the risk of fractures. Osteoporosis causes millions of bone fractures annually worldwide. It is commonly diagnosed by means of dual energy X-ray absorptiometry (DXA), a technique that provides information on areal bone mineral density (BMD, g/cm2). However, most of the low trauma fra...

BACKGROUND Model-based reconstruction algorithms have shown potentials over conventional strain-based methods in quasi-static elastographic image by using realistic finite element (FE) or bio-mechanical model constraints. However, it is still difficult to properly handle the discrepancies between the model constraint and ultrasound data, and the measurement noise. METHODS In this paper, we ex...