OBJECTIVES To evaluate the predictive capacity of umbilical, cerebral and uterine artery Doppler in women admitted for preeclampsia (PE). METHODS 190 consecutive singleton pregnancies admitted with PE were included. Umbilical, cerebral and uterine artery Dopplers were performed. The association with adverse perinatal outcome was evaluated from 2 x 2 tables and multivariately by logistic regre...

34 Pre-eclampsia represents a state of increased or prolonged vasoconstriction, partially 35 linked to the potent vasocontractile effect of isoprostanes. The process of Rho A– 36 mediated calcium sensitization is inherent to a state of prolonged contractility in many 37 smooth muscle types. The aims of this study were 1), to investigate mRNA expression 38 levels of Rho A and Rho kinase isoforms...

34 Pre-eclampsia represents a state of increased or prolonged vasoconstriction, partially 35 linked to the potent vasocontractile effect of isoprostanes. The process of Rho A– 36 mediated calcium sensitization is inherent to a state of prolonged contractility in many 37 smooth muscle types. The aims of this study were 1), to investigate mRNA expression 38 levels of Rho A and Rho kinase isoforms...

OBJECTIVE To investigate the hypothesis that alterations in heart rate variability, peak systolic velocity variability and time-averaged velocity variability in the human umbilical artery may predict early signs of dysfunctional fetal-placental coupling in pregnancies that later develop pregnancy-induced hypertension. METHODS Doppler flow velocity recordings from the umbilical artery were per...

BACKGROUND Intrauterine growth restriction /retardation (IUGR) is defined as birth weight below the 10th percentile for a given gestational age. Placental insufficiency is the primary cause of intrauterine growth retardation in normally formed fetuses and can be identified using umbilical artery Doppler velocimetry which is a non-invasive technique. The objective of this study was to compare pe...

PURPOSE To evaluate the merit of umbilical artery Doppler study as a predictive marker of perinatal outcome in preterm small for gestational age (SGA) infants. MATERIALS AND METHODS A total of 218 patients at 27 - 36 weeks of gestational age (GA) who received antenatal umbilical artery Doppler velocimetry and delivered singleton infants with SGA. The ratio of peak-systolic to end-diastolic bl...

In fetal sheep, umbilical responsiveness to ANG II exceeds systemic vascular responsiveness. Fetal systemic vascular smooth muscle (VSM) exhibits an immature phenotype with decreased contractile protein contents, low 200-kDa myosin heavy chain (MHC) SM2, and significant nonmuscle MHC-B expression, whereas umbilical VSM phenotype is incompletely described. We tested the hypothesis that differenc...

The objective was Ephedrine, Mephentermine, and Phenylephrine was compared in the treatment of maternal hypotension following spinal anesthesia for elective cesarean delivery. The Design was Randomized, double-blind trial and Setting in Obstetric suite at a university-affiliated hospital. The Patients were sixty healthy patients electively scheduled for cesarean delivery under spinal anesthesia...