This paper is concerned with optimal strategies for drilling in an oil exploration model. An exploration area contains n1 large and n2 small oilfields, where n1 and n2 are unknown, and represented by a two-dimensional prior distribution π. A single exploration well discovers at most one oilfield, and the discovery process is governed by some probabilistic law. Drilling a single well costs c, an...

Environmental impact is a primary criterion for selecting any liquid used for filling boreholes in glaciers. Antifreeze solutions based on ethanol and other high molecular weight alcohols are among several potential fluids used for drilling deep holes in the Arctic and Antarctic glaciers. At relatively high ice temperatures in boreholes, the concentration of ethanol in the solution can be low. ...

Ubiquitylation provides a rapid alternative to control the activity of crucial cellular factors through the remodelling of a target protein. Diverse ubiquitin chains are recognized by domains with affinity for UBDs (ubiquitin-binding domains) present in receptor/effector proteins. Interestingly, some proteins contain more than one UBD and the preservation of this structure in many species sugge...

NEMO is the regulatory subunit of the IkappaB kinase (IKK) in NF-kappaB activation, and its CC2-LZ region interacts with Lys63 (K63)-linked polyubiquitin to recruit IKK to receptor signaling complexes. In vitro, CC2-LZ also interacts with tandem diubiquitin. Here we report the crystal structure of CC2-LZ with two dimeric coiled coils representing CC2 and LZ, respectively. Surprisingly, mutagene...

Residual stresses are balanced, non-uniform, undesirable, and often harmful in laminated polymer composite materials. Different methods developed to measure these composites. In this manuscript, three experimental measurement methods, namely ‘hole drilling’, ‘slitting’, ‘curvature’ considered, the results compared with those of classical lamination theory (CLT). It is demonstrated that hole dri...

distance-balanced graphs are introduced as graphs in which every edge uv has the followingproperty: the number of vertices closer to u than to v is equal to the number of vertices closerto v than to u. basic properties of these graphs are obtained. in this paper, we study theconditions under which some graph operations produce a distance-balanced graph.

Objectives. To test the hypothesis that there would be no differences in osseointegration by reducing the number of drills for site preparation relative to conventional drilling sequence. Methods. Seventy-two implants were bilaterally placed in the tibia of 18 beagle dogs and remained for 1, 3, and 5 weeks. Thirty-six implants were 3.75 mm in diameter and the other 36 were 4.2 mm. Half of the i...