Treatment of rats with desipramine (DMI) 1 hour before the subcutaneous administration of methadone increased the intensity and prolonged the duration of methadone analgesia, as determined by the hot plate method. DMI significantly reduced the analgesic ED50 of methadone from a control value of 3.4 to 1.6 or 0.5 mg/kg in rats treated with 20 or 30 mg/kg of DMI, respectively. DMI treatment also ...

The influence of close-up feed strategies on growth performance and dietary NE in light-weight feedlot steers during a 56 d receiving period was evaluated. Dietary treatments were formulated to meet the average metabolizable amino acid requirements of calves during 1) the initial 7 d; 2) the initial 14 d; and 3) the initial 21 d following arrival into the feedlot, assuming average interval DMI ...

Major objectives were to evaluate effects of three schemes of bST-supplementation of Holstein cows (142.8 mg/14 d, POSILAC) during the prepartum and/or postpartum periods through 63 d (±3 d) of lactation. Measures evaluated the potential of treatments to improve body weight (BW) and body condition score (BCS), provoke changes in plasma concentrations of somatotropin (ST) and IGF-I, and improve ...

Intake prediction equations of NRC based on initial BW and dietary NE(m) concentration were evaluated with a commercial feedlot database consisting of 3,363 pen means collected from 3 feedlots over a 4-yr period. The DMI predicted by NRC equations had significant (P < 0.01) mean and linear biases across the range of observed DMI in the database. In general, DMI was overpredicted by the NRC equa...

In order to investigate the relationship between insulin to glucagon ratio and metabolic factors in transitional period of dairy cows, 28 cows heifers with body condition score of 3.25- 3.75 were selected. Dairy cows received close up diet, from 21 days prepartum until parturition and lactation diet according to nutritional requirements after parturition. Blood was sampled at 10 days before and...

Transition of primiparous heifers to the milking herd is a period with multiple stressors. The objective of these studies was to determine effects of parlour experience and prepartum milking (pre-milking) on behavioural and physiological indicators of stress after calving. Two experiments were conducted, one was in a free-stall housing confinement system and the second was in a modified grazing...

In this study, we assessed the effects of increasing amounts linseed oil (LSO) in corn silage-based diets on enteric CH4 production, rumen fermentation characteristics, protozoal population, nutrient digestibility, N utilization, and milk production. For purpose, 12 multiparous lactating Holstein cows (84 ± 28 d milk; mean SD) fitted with ruminal cannula were used a replicated 4 × Latin square ...

Prepartum and postpartum depression have negative, and sometimes devastating, effects on women and their families. As inflammatory processes are related to depression in general, we hypothesized that inflammatory perturbations, prepartum and postpartum, contribute to triggering and worsening of symptoms of peripartum depression. We conducted a longitudinal preliminary study on 27 women at high ...

The NRC (1996) equation for predicting DMI by growing-finishing beef cattle, which is based on dietary NEm concentration and average BW(0.75), has been reported to over- and underpredict DMI depending on dietary and animal conditions. Our objectives were to 1) develop broadly applicable equations for predicting DMI from BW and dietary NEm concentration and 2) evaluate the predictive value of us...

In two consecutive years, primi- and multiparous, spring-calving Hereford and Hereford x Angus cows (n = 32, yr 1; n = 42, yr 2) were used to determine the effects of supplements and lactational status on forage intake, digestibility, and energy intake. Cows were randomly alloted to treatments after being blocked by age, breed, and weight. Supplements fed during gestation provided .55 kg/d of C...