It is now clear that the two broad sets of reactions in the ubiquitin-proteasome system (UPS), the conjugative and degradative steps, are intricately coupled in vivo and that there are numerous factors that aid in the handling and delivery of ubiquitylated proteins to the proteasome. The report from Richly et al (2005)[this issue of Cell]) suggests how several of the known players in this proce...

Validation activities for the Medium Resolution Imaging Spectrometer (MERIS) primary radiometric products were carried out using data collected at the Acqua Alta Oceanographic Tower (AAOT) in the northern Adriatic Sea. The intercomparison between the normalized water leaving radiances LWN computed from atmospherically corrected MERIS data and above water radiometric measurements taken with the ...

Collaborative Networked Organisations (CNO) face the same if not even harder problems when trying to transform towards a learning organisation. Small and medium sized organisations which still represent the motor for job creation in Europe often respond to market turbulence by engaging in nonhierarchical CNOs such as Virtual Enterprises. A proven method to support learning in distributed set-up...

the asia-pacific region generates over half of global economic activity (54.2%) and about 43.7% of global trade, and is the most dynamic region in the global economy. at the core of this is an increasingly dynamic, vibrant and entrepreneurial small-medium sized enterprise sector. advances in information and communications technology, market liberalisation and moves towards closer regional econo...

The following paper presents the results of the outcome evaluation of StartBiz; an online tool for start-ups in Switzerland. StartBiz is provided by the State Secretariat for Economic Affairs (SECO) and allows start-ups to enroll with trade registers, VAT, social insurances and accident insurances without any addi‐ tional fees directly via the internet. The outcome evaluation was required to le...

development of modern economy without private sector and high vigilance entrepreneurs is vital to identify opportunities and use of opportunities around the world. in this regard, identifying the influencing factors on emergence and development of entrepreneurship culture can be effective to promote entrepreneurship in our country. for this purpose, the main issue in this study is to identify t...