BACKGROUND Gout is a metabolic disease that can manifest as acute or chronic arthritis, and deposition of urate crystals in connective tissue and kidneys. It can either manifest as acute arthritis or chronic tophaceous gout. CASE PRESENTATION We present a 39-year-old male patient who developed acute arthritis during his hospital course. Later on, after a careful physical examination, patient ...

The necropsy of an 84-year-old woman with painful polyarticular gout showed a severe erosion of the L2 vertebral body due to sodium urate deposition. The radiological signs of this tophus had existed for many years; it had caused recurrent pain but no neurological complications. A small tophus and a Schmorl's node on 2 neighbouring thoracic vertebrae permitted the differentiation between verteb...

Gout is the most common cause of inflammatory arthritis affecting at least 1% of the population in industrialized countries. It is closely associated with hyperuricemia and is characterized by formation and reversible deposition of monosodium urate crystals in joints and extra-articular tissues. Several studies suggest that the prevalence and incidence of gout are rising. Numerous risk factors ...

Calcium deposits are often seen at tendon insertions around the joint and causes acute periarthritis mimicking gouty arthritis or pseudogout.1 It is reported that calcium deposition other thanmonosodium urate or calciumpyrophosphate dihydrate occurs in articular cartilages or menisci of the knee with aging or progression of osteoarthritis.2,3 However, the size of the deposit of calcium-containi...

MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthrit...

Gout is an autoinflammatory disorder associated with deposition of monosodium urate (MSU) crystals in joints and periarticular tissues. Recent advances suggest that the innate immune system may drive the gouty inflammatory response to MSU. These findings prompt questions concerning how the innate immune system recognizes MSU and the identities of the receptors involved. In this issue of the JCI...

Urate is transported against an electrochemical gradient into the lumen of the lower Malpighian tubule oiRhodnius. In vivo, higher urate transport rates are induced by the increase in haemolymph urate concentration that follows feeding. The induced rate of transport is sufficient to account for the amount of urate eliminated. In vitro experiments with the tsetse fly Glossina suggest a possible ...

Salicylate administered to man in sufficiently large dosage (5 to 6 or more Gm. per day) causes marked uricosuria, characterized by substantially increased urate/inulin clearance ratios attributable to inhibition of tubular reabsorption of the filtered urate. In smaller dosage (1 to 2 Gm. per day) salicylate exerts a contrary effect, retention of urate, associated with lower than normal urate/i...

Human SLC2A9 (GLUT9) is a novel high-capacity urate transporter belonging to the facilitated glucose transporter family. In the present study, heterologous expression in Xenopus oocytes has allowed us to undertake an in-depth radiotracer flux and electrophysiological study of urate transport mediated by both isoforms of SLC2A9 (a and b). Addition of urate to SLC2A9-producing oocytes generated o...

Gout is a frequent inflammatory disease induced by the deposition of monosodium urate crystals in joints and extra-articular tissues. The natural history of the disease includes four different phases: asymptomatic hyperuricemia, acute attacks, intercritical phase, and chronic tophaceous gout. Imaging techniques have several applications in the diagnosis, clinical monitoring and management of th...