We have previously demonstrated that antagonism of glutamate NMDA receptors or activation of endocannabinoid receptors could reduce experimentally induced neuroinflammation within the hippocampus of young rats. In the current study, we investigated whether pharmacological manipulation of glutamate or endocannabinoid neurotransmission could reduce naturally-occurring neuroinflammation within the...

BACKGROUND The endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake, indicating that the enzyme regulates uptake by controlling the intra- : extracellular AEA concentration gradient. However, in other FAAH-expres...

The endocannabinoid anandamide (ANA) participates in the control of cell death inducing the formation of apoptotic bodies and DNA fragmentation. The aim of this study was to evaluate whether the ANA degrading enzyme, the fatty acid amide hydrolase (FAAH), would induce cellular death. Experiments were performed in cerebellar granule neurons cultured with the FAAH inhibitor, URB597 (25, 50 or 100...

Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the...

BACKGROUND AND PURPOSE There are limited options for the treatment of neuropathic pain. Endocannabinoids, such as anandamide and 2-arachidonoyl glycerol (2-AG), are promising pain modulators and there is recent evidence of interactions between anandamide and 2-AG biosynthesis and metabolism. It has been clearly demonstrated that 2-AG degradation is mainly catalysed not only by monoacylglycerol ...

UNLABELLED Variations in environmental aversiveness influence emotional memory processes in rats. We have previously shown that cannabinoid effects on memory are dependent on the stress level at the time of training as well as on the aversiveness of the environmental context. Here, we investigated whether the hippocampal endocannabinoid system modulates memory retrieval depending on the trainin...

We study a well-known communication abstraction called Uniform Reliable Broadcast (URB). URB is central in the design and implementation of fault-tolerant distributed systems, as many non-trivial applications require with provable guarantees on message deliveries. Our focuses implementations for time-free message-passing systems that are prone to node-failures. Moreover, we aim at an even more ...

In this first lecture, we begin by introducing the Chinese Restaurant Process. After a brief review of finite mixture models, we describe the Chinese Restaurant Process mixture, where the latent variables are distributed according to a Chinese Restaurant Process. We end by noting a connection between Dirchlet processes and the Chinese Restaurant Process mixture. We will define a distribution on...

Suggested citation: Zelada-Castro, H, Rodríguez-Borda, J, Flores-Liñan, H, León-Manco, J, Wetzel, EJ & CárdenasCallirgos, J. Neotropical Helminthology, vol. 7, N°1, jan-jun, pp. 155 166. 1 Alberto Hurtado School of Medicine. Cayetano Heredia Peruvian University. Av. Honorio Delgado 430, Urb. Ingeniería, S.M.P. Lima Peru. E-mail: [email protected] 2 Alberto Cazorla Talleri School of Sciences...

Many reports suggest that the discovery of microRNAs (miRNAs) might provide a novel therapeutical target for many diseases, even of human cancers; however, there are no reports on the role of miR-597 in human cancers. In the present study, by detecting mRNA expression with qRT-PCR, compared with the adjacent normal tissues we found that miR-597 was significantly downregulated in breast cancer t...