A new non isotopic immunoassay based on latex particle agglutination has been developed for the determination of albumin in urine. The assay consists in incubating the urine sample for 30 min at 37 degrees C with latex particles coated with a specific antibody, followed by quantification of the resulting agglutination by particle counting or turbidimetry. The stability of antibody-coated partic...

OBJECTIVE To determine the influence of microalbuminuria on pregnancy outcome in women with type 1 diabetes. RESEARCH DESIGN AND METHODS This prospective cohort study took place at the Obstetric Clinic at National University Hospital, Copenhagen, from January 1996 to February 2000. All Caucasian women with type 1 diabetes, unselected from the eastern part of Denmark, with a living fetus befor...

The aim of the study was to determine whether a reduced nocturnal fall in blood pressure would increase the risk of microvascular complications in normoalbuminuric and normotensive type 1 diabetics. The study included 139 type 1 diabetic patients with urinary albumin excretion <30 mg/24 h and casual blood pressure <130/80 mm Hg. Direct ophthalmoscopy and 24-h ambulatory blood pressure were perf...

BACKGROUND Microalbuminuria is associated with increased risk of cardiovascular events. We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours). METHODS AND RESULTS From the Prevention of Renal and Vascular Endstage Disease (PREVEND) cohort (n=8592), 1439 subjects fulfilled...

BACKGROUND Micro-albuminuria has been well established as one of the risk factors of metabolic syndrome (MetS). However, the association of MetS and its components with low-grade albuminuria among those with normal urinary albumin excretion has not been clearly elucidated in Chinese population. METHODOLOGY AND FINDINGS A cross-sectional study was conducted among 9,579 participants with normal...

1242 CLINICALCHEMISTRY, Vol.31, No.7, 1985 Clin Chem 29, 355-357 (1983). 2. Viberti G, Keen H. The patterns of proteinuria in diabetes mellitus: Relevance to pathogenesis and prevention of diabetic nephropathy. Diabetes 33,686-692(1984). 3. Garner RC, Walpole AL, Rose FL. Testing of some benzidine analogues for microsomal activation to bacterial mutagens. Cancer Lett 1, 39-42 (1975). 4. Miles O...

INTRODUCTION The aim of the present study was to determine the effect of sitagliptin on microalbuminuria in patients with type 2 diabetes mellitus. MATERIALS AND METHODS A total of 85 patients with type 2 diabetes mellitus (age >20 years, <80 years, hemoglobin A1c [HbA1c] <8.4%) were randomized to patients taking sitagliptin 50 mg or other oral glucose-lowering agents. The following parameter...

Rheumatoid arthritis (RA) is associated with significant cardiovascular (CV) morbidity and mortality. Increased urinary albumin excretion is a marker of CV risk. There are only few data on urinary albumin excretion in RA patients. Aim of the present study was to investigate urinary albumin excretion in RA patients and analyze, whether there is an association between urinary albumin excretion an...

Urine samples from neonates admitted to a special care baby unit were analysed to establish ranges for urinary retinol binding protein, albumin, and total protein concentrations in healthy term and preterm infants and to investigate changes seen in disease states. Urinary excretion of retinol binding protein was greater in preterm infants and was increased in sick infants. This was greater than...