BACKGROUND Metabolism of human chorionic gonadotropin (hCG) in the serum and kidney yields the terminal urinary product hCG beta-core fragment (hCGbetacf), comprising two disulfide-linked peptides (beta6-beta40 and beta55-beta92) of which one (beta6-beta40) retains truncated N-linked sugars. Hyperglycosylated hCGbetacf may indicate choriocarcinoma or Down syndrome, but the glycosylation profile...

Human chorionic gonadotropin (hCG) preparations contain activity against HIV type 1 (HIV-1). However, there has been controversy about whether some biological activities of hCG beta-subunit (hCGbeta) preparations are caused by the beta-subunit itself or other proteins present in the preparations. We report here the purification, characterization, and identification of three enzymes with anti-HI...

Introduction: Transitional cell carcinomas (TCC) of the upper urinary tract constitute only 7% of urothelial carcinomas. The majority of upper urinary tract TCC arises from the renal pelvis, followed by the ureter. The majority of the patients are presented with microscopic or macroscopic haematuria, flank pain, or symptoms due to metastasis; however, it can be asymptomatic in 10-15%. Case pre...

Introduction: Transitional cell carcinomas (TCC) of the upper urinary tract constitute only 7% of urothelial carcinomas. The majority of upper urinary tract TCC arises from the renal pelvis, followed by the ureter. The majority of the patients are presented with microscopic or macroscopic haematuria, flank pain, or symptoms due to metastasis; however, it can be asymptomatic in 10-15%. Case pre...

AIMS To examine long term survival of women with primary and recurrent cervical carcinoma in relation to (1) excretion of beta-core (a urinary metabolite of beta human chorionic gonadotrophin (beta hCG)) and (2) beta hCG immunostaining of the tumours, to determine the suitability of these markers for assessing prognosis. METHODS This was a prospective observational study undertaken in a gynae...

Abstract Study question How can stimulation of corpus luteum in the luteal phase with human chorionic gonadotropin (hCG) improve obstetric and perinatal outcomes? Summary answer There is currently no evidence that use hCG as an alternative treatment for luteal-phase support (LPS) improves outcomes. What known already are different approaches providing LPS, although none have shown differences p...

hCG exists in two analogous structures, as typified by the hormone hCG which binds an LH/hCG hormone receptor and the TGFß receptor binding autocrine hyperglycosylated hCG. Both share a common α-subunit and ß-subunit amino acid sequence. From the common hormone hCG and autocrine hyperglycosylated hCG structures there are seven common hCG variants with wildly varying hormone hCG or autocrine hyp...