OBJECTIVES to evaluate the degree of cadmium induced glomerular impairment and to assess the dose-response relation between cadmium dose and the prevalence of glomerular dysfunction. METHODS A comparison of glomerular filtration rates (GFR) assessed by Cr-EDTA clearance was made in 42 solderers previously exposed to cadmium for at least five years. Blood and urine data were collected at healt...

Estrogen-mimicking chemicals, such as cadmium, may be associated with increased susceptibility to hormone-dependent cancers, though supporting data are sparse, particularly for endometrial cancer. The Health and Environmental Exposure Research (HEER) study worked with the Arkansas Central Cancer Registry, Iowa Cancer Registry and Missouri Cancer Registry to obtain names of women diagnosed with ...

Long-term exposure to cadmium may cause kidney and bone damage. Urinary cadmium is commonly used as the dose estimate for the body burden of cadmium. However, elevated levels of cadmium in the urine may reflect not only high levels of cadmium dose but also renal dysfunction. In this study we used blood cadmium as the dose estimate. In addition, we analyzed blood lead. We examined 479 men and 54...

Prolonged exposure of workmen in the alkaline accumulator industry to cadmium oxide dust led in many cases to the appearance of protein in the urine (Friberg, 1950). This observation has been confirmed in a preliminary publication (Smith, Kench, and Lane, 1955). Proteinuria has also been observed in men exposed to cadmium fume (Bonnell, 1955). There is reason to believe that this urinary protei...

When the working environment in a small cadmium-pigment manufacturing plant was investigated cadmium concentrations in respirable dust were found to be considerably above the hygiene standard recommended by the British Occupational Hygiene Society. Cadmium concentrations in blood and urine of exposed workers, both present and past employees, were determined. The six men who had worked in the pr...

The effect of nickel on cadmium nephro-toxicity and hepato-toxicity in rats was investigated. The administration of nickel (6 mg per kg, i.p., three days) or cadmium (6 mg per kg, i.m., once) significantly enhanced the urinary excretion of alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT), amino acids, and proteins. In addition, it increased the ...

Cadmium (Cd) is a dangerous occupational and environmental toxin. Exceeding its permissible weekly uptake in meals is a disturbing phenomenon. The aim of this study is to assess the effect of long-term uptake of cadmium chloride on selected biochemical parameters and oxidative stress biomarkers in animal models. Long-term intoxication with cadmium chloride elevated blood serum concentration of ...

Health examinations by a revised method aimed at detecting renal tubular dysfunctions more effectively were conducted on the general population aged 50 years and over in cadmium-polluted areas (1826 persons) and control areas (1611 persons) in four prefectures in Japan in 1976. Although detailed analysis of the data is not yet completed, some of the results obtained are described here. The prev...

Cadmium poisoning has been reported from many parts of the world. It is one of the global health problems that affect many organs and in some cases it can cause deaths annually. Long-term exposure to cadmium through air, water, soil, and food leads to cancer and organ system toxicity such as skeletal, urinary, reproductive, cardiovascular, central and peripheral nervous, and respiratory systems...