BACKGROUND Epidemiological studies have revealed a relationship between early growth restriction and the subsequent development of insulin resistance and type 2 diabetes. Ligation of the uterine arteries in rats mimics uteroplacental insufficiency and serves as a model of intrauterine growth restriction (IUGR) and subsequent developmental programming of impaired glucose tolerance, hyperinsuline...

Leiomyomas are the most common mesenchymal neoplasms. Smooth muscle cells with variable amounts of fibrous stroma make up these benign tumors. The tumor occurs frequently in uterus 20–30% women reproductive age. Uterine leiomyosarcoma (uLMS/LMS) is a rare cancer originating from smooth lining walls uterus. We report case postmenopausal 65 years presented retention urine, diagnosed as LMS on his...

Uterine leiomyomas are the benign tumors arising from muscle cells of uterus. These most common observed in reproductive age group and is seen around 2% pregnant women. The effect fibroids on pregnancy varies according to number, size their location. Most patients asymptomatic. Recent literature suggests myomectomy during caesarean section safe well selected cases with experienced obstetrician ...

Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-γ-inducible factor, spontaneously develop uterine LMS. The IFN-γ pathway is important for control of tumor growth and invasion a...

Benign metastasizing leiomyoma (BML) is composed of well-differentiated smooth muscle cells and dense connective tissue. BML affects middle-aged women who have had previous hysterectomies due to a histologically benign-appearing uterine leiomyoma. We report here on a case of BML from the uterine leiomyoma in a 39-year-old woman that involved the soft tissues, skeletal muscles, lungs and breasts...

Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. We presen...

Leiomyoma, benign tumors of smooth muscle origin, is one of the commonest uterine tumours in the reproductive age group and originates from the myometrium. While most leiomyomas are asymptomatic, they can grow and cause heavy and painful menstruation, painful sexual intercourse and urinary frequency and urgency. Extra uterine leiomyomas are rare, usually benign, they may theoretically arise fro...

BACKGROUND Use of morcellation during laparoscopic hysterectomy may result in seeding of uterine tissue throughout the abdominal cavity and development of 'iatrogenic' leiomyomatosis peritonealis disseminata. CASE Two years after a supracervical laparoscopic hysterectomy a 42-year-old parous women presented with abdominal pain and bloating. CT scans and subsequent surgical exploration reveled...

Uterine leiomyomata are the most common gynecological benign tumors arise from the smooth muscle cells of the myometrium. The pathogenesis of fibroids is still unclear. Leiomyomas are found in more than half of women over age 35. About 70% of Caucasian women and 80% of African American women have uterine leyomyomata above 50 years of age. Most of patients have small uterine leiomyoma. Giant ute...

We estimated the cellular myosin, actin, and tropomyosin contents of vascular smooth muscle from (1) seven major arteries, (2) seven large veins, and (3) the first through third order branches of the uterine vasculature to determine whether variations in the contractile apparatus contribute to the functional diversity of vascular smooth muscle. We obtained the estimates by quantitative densitom...