introduction: the majority of leukemia patients are acute leukemia patients, so that about 70.8% lymphoblastic leukemia were acute lymphoblastic leukemia (all) patients and 66.4 % of myeloid leukemia patients were acute myeloid leukemia (aml) in tehran metropolitan. during the last two decades, intensification of therapy by the use of high-dose cytarabine allogeneic stem cell transplantation in...

high-dose chemotherapy and autologous stem cell transplantation (sct) have become an effective care for many patients with hematological malignancies. harvesting the stem cells is one the most important parts of sct. the two most commonly used mobilization regimens are the use of granulocyte colony-stimulating factor (g-csf) or g-csf plus chemotherapy. however, about 10-30% of patients are unab...

background β-thalassemia is a prevalent genetic disease in mediterranean countries. the most common treatments for this disease are blood transfusion plus iron chelation (btic) therapy and bone marrow transplantation (bmt). patients using these procedures experience different health-related quality of life (hrqol). the purpose of the present study was to measure hrqol in these patients using 2...

BACKGROUND Although bone marrow (BM) or mobilized peripheral blood (PB) is frequently used as the source of hematopoietic stem cells, hematopoietic stem cell transplantation (HSCT) using cord blood (CB) is gradually gaining popularity in many countries. However, BM or PB is still preferred over CB in Korea. Therefore, we tried to assess the awareness of CB transplantation (CBT) among domestic H...

Patients who have undergone bone marrow transplantation (BMT) remain immunodeficient for months to years posttransplantation. To evaluate the basic molecular events underlying reconstitution of the humoral immune response, we have performed a detailed nucleotide sequence analysis of VH6 containing rearrangements in circulating B cells from two BM donor/recipient pairs. Our results show that the...

Granulocytic sarcoma is a localized extramedullary solid tumor composed of immature myeloid cell and is usually associated with acute myeloid leukemia or myelodysplastic syndrome. Although it can involve any site, commonly in lymph nodes, skin, bone and soft tissue, the involvement of breast is unusual. Especially, the involvement of the breast as a pattern of relapse after bone marrow transpla...

introduction: the thalassamias refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of  one or more of globin chains (α,β, γ, δβ,γδβ, δ and εγδβ).the main cure available today for thalassamia is bone marrow transplantation (bmt)  from compatible donor.on december 3, 1981 a 14-month-old child with β-thalassemia major recieved bmt from his hla-identical sister in ...

Despite the fact that a number of therapeutic modalities have shown promise in treatment spinal cord injury (SCI), focusing solely on one aspect recovery will not lead to successful and useful regeneration people. The current study targets an integrated approach neuroprotection rehabilitation strategies treat injury, increasing nerve functional through sensorimotor training cell transplantation...

Longitudinal data were analysed on the lung function of 25 of 29 survivors of childhood leukaemia or lymphoma, who had been conditioned with cyclophosphamide and total body irradiation before allogeneic bone marrow transplantation, to test whether children are particularly vulnerable to pulmonary damage after transplantation. None developed chronic graft-versus-host disease. Transfer factor and...

Autologous bone marrow transplantation has curative potential in patients with both Hodgkin's disease and non-Hodgkin's lymphoma who have relapsed following conventional therapy. Autologous bone marrow transplantation allows administration of higher doses of chemotherapy, radiation therapy, or combined-modality therapy than is otherwise possible, often resulting in increased cure rates (20% to ...