an efficient and green protocol for the synthesis of pyrazoles derivatives by one-pot reaction of different 1,3-dicarbonyl compounds with hydrazines/hydrazides has been developed using nano-sulfated zirconia, nano-structured zno, nano-g-alumina and nano-zsm-5 zeolites, as the catalyst. the optical properties of the nano-structured catalysts and organic molecules were studied. the advantages of ...

Herein, we report an efficient method for synthesis of novel selenocyanates amino pyrazole, uracil, and isoxazole derivatives using in situ triselenium dicyanide from the combination malononitrile selenium dioxide DMSO medium. Using same but changing stoichiometry reagents sequence addition temperature, symmetrical selenoethers pyrazoles uracils were prepared good yields. Furthermore, utilized ...

Libraries of DNA-tagged compounds are a validated screening technology for drug discovery. They are synthesized through combinatorial iterations of alternated coding and preparative synthesis steps. Thus, large chemical space can be accessed for target-based screening. However, the need to preserve the functionality of the DNA tag severely restricts the choice of chemical methods for library sy...

An efficient and green protocol for the synthesis of pyrazoles derivatives by one-pot reaction of different 1,3-dicarbonyl compounds with hydrazines/hydrazides has been developed using nano-sulfated zirconia, nano-structured ZnO, nano-g-alumina and nano-ZSM-5 zeolites, as the catalyst. The optical properties of the nano-structured catalysts and organic molecules were studied. The advantages of ...

......................................................................................................................................... ii Abbreviations and Atom Colour Scheme .................................................................................... iii Chapter 1: Introduction .............................................................................................................

Enaminone 1 was reacted with hydrazonoyl halides 2a-d to yield 3,4-disubstituted pyrazoles 6a-d. Coupling with arenediazonium chlorides afforded the 2-(arylhydrazono)-3-(1-naphthalenyl)-3-oxopropionaldehydes 13a-c. Compounds 13 could be utilized for the synthesis of a variety of arylpyrazoles, arylazolopyrimidines, and pyridazinones via reaction with hydrazines, aminoazoles, and active methylen...

The five membered heterocyclic compounds pyrazolines were found as the core structure in a large variety of compounds. Pyrazoles have been the recent target of numerous methodologies, mostly due to their prevalence as scaffolds in synthesis of bioactive compounds and reactions in different media. In this review, an attempt is made to provide an up to date developments in the synthetic strategie...