Snake venom toxin (SVT) from Vipera lebetina turanica contains a mixture of different enzymes and proteins. Peroxiredoxin 6 (PRDX6) is known to be a stimulator of lung cancer cell growth. PRDX6 is a member of peroxidases, and has calcium-independent phospholipase A2 (iPLA2) activities. PRDX6 has an AP-1 binding site in its promoter region of the gene. Since AP-1 is implicated in tumor growth an...

Secretory phospholipasesA(2) (sPLA(2)s) form a large family of structurally related enzymes widespread in nature. Herein, we studied the inhibitory effects of sPLA(2)s from Vipera lebetina (VLPLA(2)), Vipera berus berus (VBBPLA(2)), and Naja naja oxiana (NNOPLA(2)) venoms on (i) human platelets, (ii) four different bacterial strains (gram-negative Escherichia coli and Vibrio fischeri; gram-pos...

BACKGROUND Snake bites are one of the significant health problems in the tropical and subtropical regions. Snake bite is a common medical emergency in Iran, and the epidemiological features and management of such cases vary from region to region. OBJECTIVES This present research study was conducted to obtain new information about the epidemiology of snake bites in the region of Kashan, locate...

ilam province in southwest iran possesses varied climatic and geographical conditions leading to rich biodiversity. an investigating of the status of snakes in the province was carried out from june 2005 to march 2010. a total of 103 specimens were collected and identified. six families, 20 genera, and 26 species are represented, including boidae: eryx (eryx) jaculus turcicus; colubridae: colub...

Cognition of technical systems, as the ability to perceive situations, to learn about favorable behavior, and to autonomously generate decisions, adds new attributes to safety issues. The system can cope with heavily changing conditions but its future behavior is not known a-priori. Therefore, present software solutions to safety like a comprehensive analysis of the specification and its implem...

The goal of this study was to identify new compounds from venoms able to modulate sperm physiology and more particularly sperm motility. For this purpose, we screened the effects of 16 snake venoms cleared of molecules higher than 15 kDa on sperm motility. Venoms rich in neurotoxins like those from Oxyuranus scutellatus scutellatus or Daboia russelii, were highly potent inhibitors of sperm moti...

The venoms extracted from a colubrid snake [Malpolon monspessulanus (Hermann)], seven viperids [Montivipera xanthina (Gray), Montivipera wagneri Nilson &Andrén, Vipera ammodytes (Linnaeus), Vipera kaznakovi (Nikolsky), Vipera eriwanensis (Bonaparte), Vipera barani Böhme & Joger, Macrovipera lebetina (Linnaeus)] and an elapid snake [Walterinnesia aegyptia (Lataste)] collected from various region...

The coagulation factor X activator from Russell's viper venom (RVV-X) is a heterotrimeric glycoprotein. In this study, its three subunits were cloned and sequenced from the venom gland cDNAs of Daboia siamensis. The deduced heavy chain sequence contained a C-terminal extension with four additional residues to that published previously. Both light chains showed 77-81% identity to those of a homo...