Clinical responses to anti-tumor monoclonal antibody (mAb) treatment have been regarded for many years only as a consequence of the ability of mAbs to destroy tumor cells by innate immune effector mechanisms. More recently, it has also been shown that anti-tumor antibodies can induce a long-lasting anti-tumor adaptive immunity, likely responsible for durable clinical responses, a phenomenon tha...

Fifteen fibrosarcomas, surgically excised from presumed sites of injection in dogs, and 10 canine fibrosarcomas excised from sites not used for injection were histologically and immunohistochemically compared with 20 feline post-vaccinal fibrosarcomas. Canine fibrosarcomas from presumed injection sites were of grade I (3), of grade II (4) and grade III (8). Two fibrosarcomas from non-injection ...

Leptospirosis caused by infection with pathogenic leptospires, which is the most prevalent zoonotic disease in the world. The outer membrane proteins (OMPs) of pathogenic leptospires such as LipL41 play a crucial role in pathogenesis of this disease. Therefore a major challenge to develop an effective vaccine against leptospirosis is application of basic research on the OMPs of leptospires to i...

Monoclonal antibodies (Mabs) were produced against the early Polish strains of infectious bursal disease virus (IBDV) isolated from subclinical cases of Gumboro disease between 1978 and 1980. Splenocytes from immunized mice were fused to myeloma cells and hybridomas producing antibodies against homologous and different pathotype of IBDVs were selected by indirect ELISA, immunoperoxidase, ELISA-...

In order to investigate the prevalence and track the genetic evolutions of the circulated infectious bronchitis virus (IBV) strains and their prevalence in Assiut, Egypt, partial S1 gene amplification and sequencing were done during 2013-2014. Three infectious bronchitis virus (IBV) strains with the following accession numbers (KR003438, KR003439 and KR003440 respectively) were detected from 21...

The human anti-rabies pre-exposure treatment currently used in Brazil, employing a 1-ml dose of suckling mouse brain vaccine (SMBV) administered on days 0, 2, 4 and 28, was compared to an alternative treatment with two 1 ml-doses on day 0, and one 1 ml-dose injected on days 7 and 21. The latter induced higher virus-neutralizing antibody (VNA) titers on day 21. Both Brazilian rabies vaccines pro...

Characteristic vaccinal and herpetic lesions, including Guarnieri bodies and acidophilic nuclear inclusions respectively, regularly occur in rabbit corneas infected and cultivated in vitro according to the method here described.

Passively administered anti-tumor monoclonal antibodies (mAbs) rapidly kill tumor targets via FcγR-mediated cytotoxicity (ADCC), a short-term process. However, anti-tumor mAb treatment can also induce a vaccinal effect, in which mAb-mediated tumor death induces a long-term anti-tumor cellular immune response. To determine how such responses are generated, we utilized a murine model of an anti-t...