نتایج جستجو برای: validation study

تعداد نتایج: 4087172  

Journal: :Journal of the American Medical Informatics Association : JAMIA 2014
Xia Jiang Binghuang Cai Diyang Xue Xinghua Lu Gregory F Cooper Richard E Neapolitan

OBJECTIVE The objective of this investigation is to evaluate binary prediction methods for predicting disease status using high-dimensional genomic data. The central hypothesis is that the Bayesian network (BN)-based method called efficient Bayesian multivariate classifier (EBMC) will do well at this task because EBMC builds on BN-based methods that have performed well at learning epistatic int...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Chand Khanna Timothy M Fan Richard Gorlick Lee J Helman Eugenie S Kleinerman Peter C Adamson Peter J Houghton William D Tap Danny R Welch Patricia S Steeg Glenn Merlino Poul H B Sorensen Paul Meltzer David G Kirsch Katherine A Janeway Brenda Weigel Lor Randall Stephen J Withrow Melissa Paoloni Rosandra Kaplan Beverly A Teicher Nita L Seibel Malcolm Smith Aykut Uren Shreyaskumar R Patel Jeffrey Trent Sharon A Savage Lisa Mirabello Denise Reinke Donald A Barkaukas Mark Krailo Mark Bernstein

Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with osteosarcoma. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for patients with osteosarcoma in more than 30 years. On the basis of our growing understanding of metasta...

2005
Letizia Jaccheri L. Jaccheri

In the framework of the general goals of this book, which are to discuss the state of the art of software process topics and provide practitioners with a practical view of the developed methods, I use my own experience as a process modeling researcher over the last fifteen years to make my own contribution to the goals. I will address the following questions. How have process modeling researche...

2015
Robert J. B. Goudie Roman Hovorka Helen R. Murphy David Lunn

We consider situations, which are common in medical statistics, where we have a number of sets of response data, from different individuals, say, potentially under different conditions. A parametric model is defined for each set of data, giving rise to a set of random effects. Our goal here is to efficiently explore a range of possible 'population' models for the random effects, to select the m...

2014
Justin Bedő David Rawlinson Benjamin Goudey Cheng Soon Ong

Given the difficulty and effort required to confirm candidate causal SNPs detected in genome-wide association studies (GWAS), there is no practical way to definitively filter false positives. Recent advances in algorithmics and statistics have enabled repeated exhaustive search for bivariate features in a practical amount of time using standard computational resources, allowing us to use cross-...

2017
Lin Song Cui-Yao He Nan-Ge Yin Fang Liu Yun-Tao Jia Yao Liu

Population pharmacokinetic (PPK) modelling is an easy and impartment method for estimating drug concentration for use inindividualized therapy, especially for young patients and to help protect drug-induced diseases. The purpose of this study was to develop a PPK model for effective dosing of vancomycin in Chinese neonates and young infants. The PPK modelling tool Phoenix® NLME™ was use to asse...

2015
Federico Andreoli Alberto Del Rio

Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and progression of many physiopathological processes. As a result, research in epigenetic grew at a fast pace in the last decade. In particular, the study of histone post-translational modifications encountered an extraordinary progression and many modifications have been characterized and associated to fundamen...

Journal: :Journal of nutrigenetics and nutrigenomics 2013
Maria L Mansego Fermín I Milagro Javier Campión J Alfredo Martínez

Epigenetic mechanisms are likely to play an important role in the regulation of metabolism and body weight through gene-nutrient interactions. This review focuses on methods for analyzing one of the most important epigenetic mechanisms, DNA methylation, from single nucleotide to global measurement depending on the study goal and scope. In addition, this study highlights the major principles and...

Journal: :Acta orthopaedica Belgica 2016
Matthias D Wimmer Thomas M Randau Max J Friedrich Milena M Ploeger Jan Schmolder Andreas C Strauss Peter H Pennekamp Patrick Vavken Sascha Gravius

Prosthetic joint infections are a major challenge in total joint arthroplasty, especially in times of accumulating drug resistancies. Even though predictive risk classifications are a widely accepted tool to define a suitable treatment protocol a classification is still missing considering the difficulty in treating the -causative pathogen antibiotically. In this study, we present and evaluate ...

2017
Jayne-Louise E. Pritchard Tracy A. O’Mara Dylan M. Glubb

The development of new drugs has become challenging as the necessary investments in time and money have increased while drug approval rates have decreased. A potential solution to this problem is drug repositioning which aims to use existing drugs to treat conditions for which they were not originally intended. One approach that may enhance the likelihood of success is to reposition drugs again...

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