I read the article titled " Fine needle diathermy – A choice for managing corneal vascularization " and written by Thatte S (2011) with great interest as corneal vascularization is a very common problem encountered by us also in Nepal. Most of the cases that we see are healed corneal ulcers with vascularization, in which doing an optical keratoplasty is a big challenge. The author has done a ve...

The transcription factor TBX1 is the major gene involved in 22q11.2 deletion syndrome (22q11.2DS). Using mouse models of these diseases, we have previously shown that TBX1 activates VEGFR3 in endothelial cells (EC), and that this interaction is critical for the development of the lymphatic vasculature. In this study, we show that TBX1 regulates brain angiogenesis. Using loss-of-function genetic...

Current methods for engineering vascularized tissues rely primarily on the self-organization of vascular cells (endothelial cells, pericytes, and smooth muscle cells) or their progenitors in a scaffold and/or on the recruitment of new vessels via release of angiogenic factors [1,2]. While these approaches certainly accelerate the process of graft vascularization, they still require several days...

In this paper we present several ODE systems encoding the most essential observations and assumptions about the complex hierarchical interactive processes of tumor neo-vascularization (angiogenesis). From experimental results we infer that a significant marker of tumor aggressiveness is the oscillatory behavior of tumor size, which is driven by its vascularization dynamics. To study the forces ...

In many disorders of the cornea, blood vessels invade this normally avascular tissue. Several theories have been proposed to explain the pathogenesis of corneal vascularization. Since none had received general acceptance, experimental studies of the phenomenon were begun several years ago in hamster cheek pouch chambers. These investigations which employed sequential morphologic studies during ...

The angiogenic capacity of fibroblasts is maximized through the deliver plasmids and release proteins. Consequentially, endothelial cells proliferate organize, demonstrating potential system where vascularization required.

PURPOSE To estimate cure rate following graft rejection in bilateral corneal transplants in Iranian patients with keratoconus and to determine risk factors associated with rejection. METHODS In this retrospective study, data were compiled from records of patients who had undergone bilateral penetrating keratoplasty (PK) for keratoconus between 1988 and 2007. In order to estimate cure rate in ...

OBJECTIVES Subjective ultrasonographic assessment is currently considered to be the best method of differentiation between various types of ovarian tumors. The aim of the study was to evaluate selected ultrasonographic features and CA125 levels of hormonally active ovarian tumors. MATERIAL AND METHODS A total of 1135 women with ovarian tumors were diagnosed between 2006 and 2014 at the Divisi...

Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve vascularization. The type of biomaterial influences EPC function with bioglass evoking a vascularizing response. In this study the influence of a composite biomaterial based on polylactic acid (PLA) and either 20 or 40% bioglass, BG20 and BG...

Peripheral ischemia, resulting from diminished arterial flow and defective local vascularization, is one of the main causes of impaired wound healing in diabetes. Vasodilatory prostaglandins (PGs), including PGE2 and PGI2, regulate blood flow in peripheral tissues. PGs also stimulate angiogenesis by inducing vascular endothelial growth factor. However, PG levels are reduced in diabetes mainly d...