Genome-wide association (GWA) studies to map genes for complex traits are powerful yet costly. DNA-pooling strategies have the potential to dramatically reduce the cost of GWA studies. Pooling using Affymetrix arrays has been proposed and used but the efficiency of these arrays has not been quantified. We compared and contrasted Affymetrix Genechip HindIII and Illumina HumanHap300 arrays on the...

Humans express emotional information in their facial expressions and body movements, as well as in their voice. In this chapter we consider the neural processing of a specific kind of vocal expressions, non-verbal emotional vocalizations e.g., laughs and sobs. We outline evidence, from patient studies and functional imaging studies, for both emotion-specific and more general processing of emoti...

Differing etiological explanations have been proposed to account for poor comprehenders' difficulties with reading comprehension, with some researchers emphasizing working memory deficits and others arguing for oral language weaknesses playing a key causal role. The authors contrasted these two theoretical accounts using data obtained from direct measures of working memory and from teacher rati...

A tight correspondence has been postulated between the representations of number and space. The spatial numerical association of response codes (SNARC) effect, which reflects the observation that people respond faster with the left-hand side to small numbers and with the right-hand side to large numbers, is regarded as strong evidence for this correspondence. The dominant explanation of the SNA...

This study is a verbal-pictorial analysis of the Russia-Ukraine war in Jordanian cartoons. It examines socio-political contexts related to through semiotic selected political cartoons posted on official Facebook accounts two well-known cartoonists, Emad Hajjaj and Osama Hajjaj, between January September, 2022. These show conflict eyes Arabs, who may be considered neutral distanced from conflict...

OBJECTIVE Enhanced HIV prevention interventions, such as preexposure prophylaxis for high-risk individuals, require substantial investments. We sought to estimate the medical cost saved by averting 1 HIV infection in the United States. METHODS We estimated lifetime medical costs in persons with and without HIV to determine the cost saved by preventing 1 HIV infection. We used a computer simul...

In the study of consciousness, neurophenomenology was originally established as a novel research program attempting to reconcile two apparently irreconcilable methodologies in psychology: qualitative and quantitative methods. Its potential relies on Francisco Varela's idea of reciprocal constraints, in which first-person accounts and neurophysiological data mutually inform each other. However, ...

Different theoretical interpretations have been offered in order to account for a specific language impairment termed dynamic aphasia. We report a patient (CH) who presented with a dynamic aphasia in the context of nonfluent progressive aphasia. CH had the hallmark of reduced spontaneous speech in the context of preserved naming, reading, and single word repetition and comprehension. Articulato...

Since Verkuyl (1972), we have known that a noun phrase can affect the (a)telicity of the verbal predicate. Since then, there have been both semantic and syntactic accounts of this aspectual influence of the noun (AIN). This raises the question of whether the AIN is best accounted for in semantic or syntactic terms, that is, whether it is more appropriately treated as semantic or syntactic in na...

BACKGROUND In November 2016, the ICH published a requirement for sponsors to develop a systematic, prioritised, risk-based approach to monitoring clinical trials. This approach is more commonly known as risk-based monitoring (RBM). However, recent evidence suggests that a 'gold standard', validated approach to RBM does not exist and it is unclear how sponsors will introduce RBM into their organ...