BACKGROUND AND AIMS Severe villous atrophy can be revealed with conventional white light endoscopy (WLE), however, milder grades or patchy villous atrophy are more difficult to detect. Novel endoscopic techniques such as high definition i-SCAN endoscopy with the water immersion technique (i-SCAN-HDWI) may provide the ability to visualize duodenal villi more accurately. We aimed to determine the...

BACKGROUND AND AIMS The causative molecular pathways underlying the pathogenesis of coeliac disease are poorly understood. To unravel novel aspects of disease pathogenesis, we used microarrays to determine changes in gene expression of duodenal biopsies. METHODS cDNA microarrays representing 19 200 genes were used to compare gene expression profiles of duodenal biopsies from 15 coeliac diseas...

A71-year-oldwomanwas admittedwith a 7-monthhistoryofwaterydiarrhea,which had led to an unintentional 30kg (27%) of weight loss and admittance to the intensive care unit (ICU) on two separate occasions as a result of dehydration. Endoscopy and video capsule evaluation revealed villous atrophy of the entire small bowel, with fissuring, nodularity, and loss of folds, as shown for both duodenum (●"...

Fifty seven children with dermatitis herpetiformis, 18 from Finland and 39 from Hungary, were studied. Diagnostic criteria included the finding of granular IgA deposits in the skin of all patients. The mean age at onset of the rash was 7 X 2 years and favoured sites were the elbows, knees, and buttocks. Symptoms suggesting small intestinal disease were rare but in 35 (61%) of the children subto...

A 49-year-old woman with morbid obesity was found to have subtotal villous atrophy in an operative jejunal biopsy, taken when a jejunoileal bypass was created. After the operation, the patient developed marked weight loss, vomiting, hepatic failure, and a bizarre mental state with sudden losses of consciousness. Six months after the first operation the bypass was reversed but the patient develo...

Our prospective hospital-based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high-risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months-18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 (22.5%). Antigliadi...

Eighty-one patients with farmer's lung were screened for evidence of coeliac disease by assessing their clinical features, haemoglobin indices, serum vitamin B12 and folic acid levels. HLA typing was carried out and the frequency of antireticulin and other autoantibodies was determined. Two out of 21 patients selected for jejunal biopsy had subtotal villous atrophy, a further 6 had partial vill...