The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in para...

Drug resistance is a major problem in the successful treatment of cancer. Resistance to one drug is often associated with cross-resistance to other anticancer agents. This is commonly seen with the "natural product" anticancer drugs such as the Vinca alkaloids and anthracyclines. In experimental systems, specific changes in plasma membranes characterize this "multiple drug resistance." The most...

A number of vinca alkaloids, including vincristine, vinblastine, and vinorelbine, are currently used in cancer chemotherapy. These three vinca alkaloids interact differently with a range of solid and hematologic tumors. To test the possibility that the tubulin isotype composition is an important determinant in antineoplastic efficacy, we determined thermodynamic parameters for vinca alkaloid in...

Microtubule inhibitors interfere with microtubule dynamics, causing cell cycle arrest and apoptosis. These effects are responsible for the chemotherapeutic activities of members of the taxane and Vinca alkaloid families in oncology. Unfortunately, a major side effect of the taxanes and Vinca alkaloids is the development of peripheral neuropathies. Indibulin (N-[pyridin-4-yl]-[1-(4-chlorbenzyl)-...

An experiment to study the effect of inter and intra row spacing on the yielding performance of periwinkle species was conducted at Nagarjun Medicinal and Aromatic Plants Research Scheme, P. K. V., Akola (M. S.) during 1980 - 81 to 82 - 83. Three species viz., Catharanthus roseus, Catharanthus alba and Catharanthus oscillatus did not differ significantly in respect of dried foliage and root yie...

Vermicompost (VC) is a nutrient-rich material that mixed with soil, and it used in this study. Four different environments were created such as control (Soil:VC:100–0%), mix one (Soil:VC:70–30% w/w), two (Soil:VC:50–50% three (Soil:VC:40:60% well-developed roses (Vinca rosea valiant, Pelargonium peltatum, Pegasus patio) seedlings transferred to individual pots. Plant growth parameters, i.e., th...

Introduction: Vinca rosea, an important medicinal plant, is well-known for its anticancer properties especially against breast cancer. In this study, we compared the cytotoxic effects of methanolic extracts of the vegetative (young and old leaves) and reproductive (flowers) organs of this plant on a human squamous cell carcinoma using MTT assay. Methods: The cytotoxic effects of Vinca rosea'...