The treatment of 22 patients with Vincaleukoblastine is described. The main toxic effects were noted at the sites of injection, on the blood, and on the nervous system. Severe granulocytopenia with little or no depression of platelets was noted in nearly all patients. In fifteen of the 22 patients the administration of Vincaleukoblastine had measurable effects on the malignant process. Partial ...

Vincristine, an alkaloid of periwinkle plant (vinca) used in the treatment of various malignancies. The experimental group included 36 male wistar albino rats. The animals were divided into four groups of nine animals each. The animals received same dose of vincristine 1 mg/kg b.w. given intragastrically through a ne rubber catheter reaching lower third of oesophagus. Equal number of controls ...

Some biological effects of a new alkaloid, Vincaleukoblastine (VLB), are described. In mice bearing the transplantable leukemias L1210, P1534, and AKr or Ehrlich ascites tumor, treatment with VLB effectively prolonged survival. The effectiveness of treatment depended on the amount and spacing of dosage and the time of tininstitution of treatment after transplantation. A single injection of VLB ...

Administration of aqueous extracts of V. rosea flower and leaf have been found to regulate the blood sugar level in alloxan diabetic male albino rats. V. rosea therapy not only produced blood glucose homeostasis but also reversed changes in carbohydrate, protein, lipid metabolisms and metabolic and pathologic changes that took place in pancreatic islet cells, liver and kidney following a single...