Gene therapy using nucleic acids has many clinical applications for the treatment of diseases with a genetic origin as well development innovative vaccine formulations. Since in their free form are rapidly degraded by nucleases present extracellular matrices, have poor pharmacokinetics and hardly pass cellular membranes, carrier systems required. Suitable carriers that protect acid payload agai...

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International organizations, agencies and institutions have made a strong call for early diagnosis of HIV and the prompt –or even immediate-initiation of antiretroviral treatment. It doesn ́t happen the same with viral hepatitis. Hepatitis B can ́t be cured yet. There is no effective treatment to clear the infection among chronic carriers. Yet, being aware of the condition of chronic carrier allo...

International organizations, agencies and institutions have made a strong call for early diagnosis of HIV and the prompt –or even immediate-initiation of antiretroviral treatment. It doesn ́t happen the same with viral hepatitis. Hepatitis B can ́t be cured yet. There is no effective treatment to clear the infection among chronic carriers. Yet, being aware of the condition of chronic carrier allo...

In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecul...

International organizations, agencies and institutions have made a strong call for early diagnosis of HIV and the prompt –or even immediate-initiation of antiretroviral treatment. It doesn ́t happen the same with viral hepatitis. Hepatitis B can ́t be cured yet. There is no effective treatment to clear the infection among chronic carriers. Yet, being aware of the condition of chronic carrier allo...

International organizations, agencies and institutions have made a strong call for early diagnosis of HIV and the prompt –or even immediate-initiation of antiretroviral treatment. It doesn ́t happen the same with viral hepatitis. Hepatitis B can ́t be cured yet. There is no effective treatment to clear the infection among chronic carriers. Yet, being aware of the condition of chronic carrier allo...

Most of India’s carrier pool is established in early childhood, predominantly by horizontal spread due to crowded living conditions and poor hygiene. Acute and subacute liver failure is common complications of viral hepatitis in India and HBV is reckoned to be the etiological agent in 42% and 45% of adult cases, respectively. In conclusion, hepatitis B is a major public health problem in India ...