To understand the structural features that dictate the selectivity of the two isoforms of the prostaglandin H2 synthase (PGHS/COX), the three-dimensional (3D) structure of COX-1/COX-2 was assessed by means of binding energy calculation of virtual molecular dynamic with using ligand alpha-Patchouli alcohol isomers. Molecular interaction studies with COX-1 and COX-2 were done using the molecular ...

Despite a lot of research in recent years stable and realistic haptic interaction with virtual environments keeps an unsolved problem. Among different approaches the Voxmap-PointShell (VPS) method seems very promising due to constant sample rates, independent of the static environment. But there is still the stability problem to be solved globally. In this paper some adaptations based on the VP...

OBJECTIVE Virtual molecular dynamic sesquiterpenoid Pogostemon Herba (CID56928117, CID94275, CID107152, and CID519743) have screening as cyclooxygenase (COX-1/COX-2) selective inhibitor. METHODS Molecular interaction studies sesquiterpenoid compounds with COX-1 and COX-2 were using the molecular docking tools by Hex 8.0 and interactions were further visualized using by Discovery Studio Client...

Despite a lot of research in recent years stable and realistic haptic interaction with virtual environments keeps an unsolved problem. Among different approaches the Voxmap-PointShell (VPS) method seems very promising due to constant sample rates, independent of the static environment. But there is still the stability problem to be solved globally. In this paper some adaptations based on the VP...

Kanji Hioka Graduate School of Science and Engineering, Yamaguchi University 1677-1 Yoshida, Yamaguchi 753-8512, Japan [email protected] Yoshimasa Miwa Graduate School of Science and Engineering, Yamaguchi University 1677-1 Yoshida, Yamaguchi 753-8512, Japan [email protected] Chen Li Human Genome Center, University of Tokyo 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Ja...

A sample size calculation for logistic regression involves complicated formulae. This paper suggests use of sample size formulae for comparing means or for comparing proportions in order to calculate the required sample size for a simple logistic regression model. One can then adjust the required sample size for a multiple logistic regression model by a variance inflation factor. This method re...

Exact power and sample size calculation for bioequivalence studies with high order crossover designs using statistical software nQuery are presented. Such calculation can be very easily performed, and thus provides a convenient tool for practical usage.

We developed JVirGel, a collection of tools for the simulation and analysis of proteomics data. The software creates and visualizes virtual two-dimensional (2D) protein gels based on the migration behaviour of proteins in dependence of their theoretical molecular weights in combination with their calculated isoelectric points. The utilization of all proteins of an organism of interest deduced f...

In clinical research, parameters required for sample size calculation are usually unknown. A typical approach is to use estimates from some pilot studies as the true parameters in the calculation. This approach, however, does not take into consideration sampling error. Thus, the resulting sample size could be misleading if the sampling error is substantial. As an alternative, we suggest a Bayes...

Despite the growing popularity of virtual reality environments, few laboratories are equipped to investigate eye movements within these environments. This primer is intended to reduce the time and effort required to incorporate eye-tracking equipment into a virtual reality environment. We discuss issues related to the initial startup and provide algorithms necessary for basic analysis. Algorith...