We introduce here a Bayesian analysis of a classical admixture model in which all parameters are simultaneously estimated. Our approach follows the approximate Bayesian computation (ABC) framework, relying on massive simulations and a rejection-regression algorithm. Although computationally intensive, this approach can easily deal with complex mutation models and partially linked loci, and it c...

The genetic structure of Costa Rica's population is complex, both by region and by individual, due to the admixture process that started during the 15th century and historical events thereafter. Previous studies have been done mostly on Amerindian populations and the Central Valley inhabitants using various microsatellites and mitochondrial DNA markers. Here, we study for the first time a rando...

A population formed by genetic admixture of two or more source populations may exhibit considerable linkage disequilibrium between genetic loci. In the presence of recombination, this linkage disequilibrium declines with time, a fact that is often ignored when considering haplotypes of closely linked systems [e.g., Gm serum group (gamma globulins), HLA, and, more recently, restriction fragment ...

The initial contact of European populations with indigenous populations of the Americas produced diverse admixture processes across North, Central, and South America. Recent studies have examined the genetic structure of indigenous populations of Latin America and the Caribbean and their admixed descendants, reporting on the genomic impact of the history of admixture with colonizing populations...

OBJECTIVE To investigate the role of genetic admixture in explaining phenotypic variation in obesity-related traits in a sample of African-American women (n = 145) and to determine significant associations between obesity traits and admixture genetic markers. RESEARCH METHODS AND PROCEDURES Associations between genetic admixture and BMI, resting metabolic rate, fat mass, fat-free mass, and bo...

The distribution of admixture tract lengths has received considerable attention, in part because it can be used to infer the timing of past gene flow events between populations. It is commonly assumed that these lengths can be modeled as independently and identically distributed (iid) exponential random variables. This assumption is fundamental for many popular methods that analyze admixture us...

We discuss the relations between welfare enhancing price discrimination and privacy enhancing technologies, and the possible drivers of consumers’ and merchants’ acceptance of those technologies.

Five years ago, “Privacy-enhancing technologies for the Internet” [23] examined the state of the then newly emerging privacy-enhancing technologies. In this survey paper, we look back at the last five years to see what has changed, what has stagnated, what has succeeded, what has failed, and why. We also look at current trends with a view towards the future.

recently full factorial design approach has been used to assess the recycling potential of a given waste. the objective of this study is to identify the significant factors and interactions involved in maximizing compressive strength of concrete when chromium waste is used as admixture. in this respect, experimental factors at two levels, which are admixture type (chromite/ chromite+ superplas...

In Part 3 (Smith, 1951) of this series a virulenceenhancing fraction of hog gastric mucin was separated from the insoluble particulate residue. This residue had an adjuvant action on the enhancement ofthe virulence by the activefactor comparable with that already demonstrated (Smith, 1950b) for the viscosity of the original mucin. However, using a biological assay involving a medium of constant...