Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1a-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1a-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the ...

Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D ...

vitamin d is important for the development, growth, and mineralization of the skeletal in neonates and children. vitamin d is essential for intestinal absorption of calcium. vitamin d is metabolized to 25-hydroxyvitamin d and then to 1,25-dihydroxyvitamin d. pregnant women in developed countries often have insufficient serum concentrations of 25-hydroxyvitamin d and a supplementation of vitamin...

There is disturbing evidence of widespread vitamin D deficiency in many population groups, particularly within nations at high latitude. Numerous recent studies in the scientific literature associate vitamin D deficiency with a colossal increase in morbidity and mortality. Since Canada is at higher latitude, this review assesses the vitamin D status within the Canadian population. This review w...

76-years-old female with OP took alendronate weekly for 10 years till 2006, then every other week for another year and was initiated on a drug holiday. She started self-administrating SrC (680mg/day) in 2006 and continued to take daily calcium (600mg bid) and vitamin D (2000units). Serum calcium and Vitamin D (32-66ng/ml) remained normal. She continued SrC on her own till 2012, when she agreed ...

BACKGROUND There are few studies on the vitamin D status in preeclamptic women. The objective of this case-control study was to determine vitamin D status, in preeclamptic women and compare it with that of healthy pregnant controls. METHODS Forty preeclamptic women, aged 18 to 45yr and forty age- and pregnancy weight-matched healthy controls participated in the study. Serum 25-hydroxy vitamin...

Background: The role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. This study was performed to evaluate the possible protective effect of vitamins E and C, against endosulfan-induced reproductive toxicity in rats. Methods: Fifty adult male Sprague–Dawley rats were randomly divided into five groups (n=10 each). The groups included a control receivin...

Despite aggressive treatment and screening efforts, breast cancer remains the second leading cause of cancer-related deaths among women in the United States (1). Because of the large number of women dying from this disease and the toxicity of breast cancer treatments, recent efforts have focused on identifying effective cancer preventive agents. These efforts have led to the development of anti...

backgrounds: vitamin d deficiency is a public health concern even in sunny areas, so we decided to assess the prevalence of vitamin d deficiency and its related factors among university students in shiraz. methods: this cross‑sectional study was carried out on 254 (128 male and 126 female) university students. demographic questionnaires and a questionnaire on exposure to sun light and sun prote...